IP Library Granted Patent US 11,001,619
Granted Patent B2
US 11,001,619 · App. 16/281,347 · Granted May 11, 2021

GIP agonist compounds and methods

Inventors: Anne Pernille Tofteng Shelton (Glostrup, DK); Pia Nørregaard (Glostrup, DK); Maria Alexandrovna Deryabina (Glostrup, DK); Bjarne Due Larsen (Glostrup, DK); Jacob Ulrik Fog (Glostrup, DK)
Assignee: Zealand Pharma A/S
C07K14/575A61K38/22A61K45/06A61K38/00
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Quick Facts
Patent No.
US 11,001,619
App. No.
16/281,347
Granted
May 11, 2021
Kind
B2
Abstract

The present invention relates to acylated GIP analogues which have GIP agonist activity, and their use in the treatment of metabolic disorders.

Claims (14)

1. A GIP analogue represented by the formula:

(SEQ ID NO: 41)

Y-Aib-EGTFISDYSIELDK-K((19-Carboxy-nonadecanoyl)-

[(Piperazine-1-yl)-acetyl]-Peg3-Peg3)-

AAQAFIEWLLAQGPSSGAPPPS,

wherein

R 1 is H—, Ac or pGlu;

R 2 is —NH 2 or —OH;

and pharmaceutically acceptable salts thereof.

2. The GIP analogue of claim 1 , wherein said GIP analogue is compound 41:

H-Y-Aib-EGTFISDYSIELDK-K((19-Carboxy-nonadecanoyl)-

[(Piperazine-1-yl)-acetyl]-Peg3-Peg3)-AAQAFIEWLLAQ

GPSSGAPPPS-NH 2  (Compound 41),

or a pharmaceutically acceptable salt thereof.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded May 17, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063672/0342 →
RELEASE OF SECURITY INTEREST Recorded May 11, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063624/0547 →
PATENT SECURITY AGREEMENT Recorded Dec 27, 2021
From: ZEALAND PHARMA A/S
To: ZOOLANDER SA LLC
Reel/Frame 058593/0261 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2019
From: SHELTON, ANNE PERNILLE TOFTENG; NØRREGAARD, PIA; DERYABINA, MARIA ALEXANDROVNA; LARSEN, BJARNE DUE; FOG, JACOB ULRIK
To: ZEALAND PHARMA A/S
Reel/Frame 049597/0163 →
Priority Claims (2)
DK 2014 00629 · Oct 29, 2014 · national
DK 2015 00381 · Jul 4, 2015 · national
Continuity (2)
Continuation 15521631
Related Publication 20190256569A1 · Aug 22, 2019
Cited By (1)
US 12,703,729