Granted Patent
B2
US 11,001,619 · App. 16/281,347 · Granted May 11, 2021
GIP agonist compounds and methods
Inventors:
Anne Pernille Tofteng Shelton (Glostrup, DK); Pia Nørregaard (Glostrup, DK); Maria Alexandrovna Deryabina (Glostrup, DK); Bjarne Due Larsen (Glostrup, DK); Jacob Ulrik Fog (Glostrup, DK)
Assignee:
Zealand Pharma A/S
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Abstract
The present invention relates to acylated GIP analogues which have GIP agonist activity, and their use in the treatment of metabolic disorders.
Claims (14)
1. A GIP analogue represented by the formula:
(SEQ ID NO: 41)
Y-Aib-EGTFISDYSIELDK-K((19-Carboxy-nonadecanoyl)-
[(Piperazine-1-yl)-acetyl]-Peg3-Peg3)-
AAQAFIEWLLAQGPSSGAPPPS,
wherein
R 1 is H—, Ac or pGlu;
R 2 is —NH 2 or —OH;
and pharmaceutically acceptable salts thereof.
2. The GIP analogue of claim 1 , wherein said GIP analogue is compound 41:
H-Y-Aib-EGTFISDYSIELDK-K((19-Carboxy-nonadecanoyl)-
[(Piperazine-1-yl)-acetyl]-Peg3-Peg3)-AAQAFIEWLLAQ
GPSSGAPPPS-NH 2 (Compound 41),
or a pharmaceutically acceptable salt thereof.
Assignments (4)
RELEASE OF SECURITY INTEREST
Recorded May 17, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063672/0342 →
RELEASE OF SECURITY INTEREST
Recorded May 11, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063624/0547 →
PATENT SECURITY AGREEMENT
Recorded Dec 27, 2021
From: ZEALAND PHARMA A/S
To: ZOOLANDER SA LLC
Reel/Frame 058593/0261 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 26, 2019
From: SHELTON, ANNE PERNILLE TOFTENG; NØRREGAARD, PIA; DERYABINA, MARIA ALEXANDROVNA; LARSEN, BJARNE DUE; FOG, JACOB ULRIK
To: ZEALAND PHARMA A/S
Reel/Frame 049597/0163 →
Priority Claims (2)
DK 2014 00629
· Oct 29, 2014
· national
DK 2015 00381
· Jul 4, 2015
· national
Continuity (2)
Continuation
15521631
Cited By (1)