Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
1. A compound represented by Formula IB1 or a pharmaceutically acceptable salt thereof
wherein n is 1;
Q is absent;
R 1 is hydrogen or halo; and
R 7 is phenyl substituted by alkoxy having from 6 to 10 carbon atoms or phenoxy.
2. The compound or salt of claim 1 , wherein the compound is selected from the group consisting of:
N-[3-(Hexyloxy)benzyl]quinazolin-4-amine,
N-[3-(Decyloxy)benzyl]quinazolin-4-amine,
N-[4-(Decyloxy)benzyl]quinazolin-4-amine,
N-[4-(Hexyloxy)benzyl]quinazolin-4-amine.
3. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier.
4. The compound or salt of claim 1 , wherein the compound is N-(3-Phenoxybenzyl)quinazolin-4-amine.
5. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt of claim 4 and a pharmaceutically acceptable carrier.
6. A method of inhibiting a fungus ex vivo, comprising contacting a surface or the fungus with the compound or pharmaceutically acceptable salt of claim 1 .
7. A method of inhibiting a fungus ex vivo, comprising contacting a surface or the fungus with the compound or pharmaceutically acceptable salt of claim 4 .