Crystalline forms of therapeutic compounds and uses thereof

1. A method of treating an ocular disease comprising administering to a subject in need thereof a therapeutically effective amount of a crystalline form of Compound 1:

wherein the crystalline form has an X-ray powder diffraction (XRPD) pattern comprising peaks at 7-8 degrees 2θ, 12.5-13.5 degrees 2θ, 14.5-15.5 degrees 2θ, 17-18 degrees 2θ, and 26-27 degrees 2θ, or

a pharmaceutical composition comprising the crystalline form,

wherein the ocular disease is a macular edema, macular degeneration, retinopathy, glaucoma, ocular neovascularization, retinal vein occlusion, inflammatory meibomian gland disease, dry eye syndrome, blepharitis, uveitis, allergic conjunctivitis, or rosacea of the eye.

2. The method of claim 1 , wherein the crystalline form is a hydrate.

3. The method of claim 1 , wherein the pharmaceutical composition is suitable for topical administration.

4. The method of claim 1 , wherein the disease is macular edema.

5. The method of claim 4 , wherein the disease is a diabetic macular edema or cystoid macular edema.

6. The method of claim 1 , wherein the disease is a macular degeneration.

7. The method of claim 1 , wherein the disease is a retinal vein occlusion.

8. The method of claim 1 , wherein the ocular disease is retinopathy.

9. The method of claim 6 , wherein the ocular disease is age-related macular degeneration (AMD).

10. The method of claim 1 , wherein the disease is corneal neovascularization.

11. The method of claim 1 , wherein the disease is glaucoma.

12. The method of claim 1 , wherein the disease is inflammatory meibomian gland disease.

13. The method of claim 1 , wherein the disease is dry eye syndrome.

14. The method of claim 1 , wherein the disease is blepharitis.

15. The method of claim 1 , wherein the disease is uveitis.

16. The method of claim 1 , wherein the disease is allergic conjunctivitis.

17. The method of claim 1 , wherein the disease is rosacea of the eye.