Antibodies for IL-17C
The present invention provides antibodies or antibody fragments binding to human IL-17C. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment of humans having, for example, atopic dermatitis or psoriasis.
1. A nucleic acid encoding an isolated antibody or antibody fragment specific for IL-17C, wherein said antibody or antibody fragment comprises
(a) a heavy chain complementarity determining region (HCDR)1 comprising the amino acid sequence of SEQ ID NO: 7, a HCDR2 region comprising the amino acid sequence of SEQ ID NO: 8, a HCDR3 region comprising the amino acid sequence of SEQ ID NO: 9, a light chain complementarity determining region (LCDR)1 region comprising the amino acid sequence of SEQ ID NO: 13, a LCDR2 region comprising the amino acid sequence of SEQ ID NO: 14 and a LCDR3 region comprising the amino acid sequence of SEQ ID NO: 15, or
(b) a HCDR1 region comprising the amino acid sequence of SEQ ID NO: 20, a HCDR2 region comprising the amino acid sequence of SEQ ID NO: 21, a HCDR3 region comprising the amino acid sequence of SEQ ID NO: 22, a LCDR1 region comprising the amino acid sequence of SEQ ID NO: 26, a LCDR2 region comprising the amino acid sequence of SEQ ID NO: 27 and a LCDR3 region comprising the amino acid sequence of SEQ ID NO: 28.
2. A vector comprising the nucleic acid according to claim 1 .
3. A host cell comprising the vector according to claim 2 .
4. The nucleic acid according to claim 1 , wherein said encoded antibody or antibody fragment comprises:
a) a heavy chain variable region (V H ) comprising the amino acid sequence of SEQ ID NO:17 and a light chain variable region (V L ) comprising the amino acid sequence of SEQ ID NO:16; or
b) a V H comprising the amino acid sequence of SEQ ID NO:30 and a V L comprising the amino acid sequence of SEQ ID NO:29.
5. A vector comprising the nucleic acid according to claim 4 .
6. A host cell comprising the vector according to claim 5 .
7. The nucleic acid according to claim 4 , wherein said encoded antibody or antibody fragment comprises:
a) a heavy chain comprising the amino acid sequence of SEQ ID NO:43 and a light chain comprising the amino acid sequence of SEQ ID NO:42; or
b) a heavy chain comprising the amino acid sequence of SEQ ID NO:56 and a light chain comprising the amino acid sequence of SEQ ID NO:55.
8. A vector comprising the nucleic acid according to claim 7 .
9. A host cell comprising the vector according to claim 8 .
10. A nucleic acid encoding:
i) an antibody V H comprising a heavy chain complementarity determining region (HCDR)1 comprising the amino acid sequence of SEQ ID NO:7, a HCDR2 region comprising the amino acid sequence of SEQ ID NO:8, a HCDR3 region comprising the amino acid sequence of SEQ ID NO:9;
ii) an antibody V L comprising a light chain complementarity determining region (LCDR)1 region comprising the amino acid sequence of SEQ ID NO: 13, a LCDR2 region comprising the amino acid sequence of SEQ ID NO:14 and a LCDR3 region comprising the amino acid sequence of SEQ ID NO:15;
iii) an antibody V H comprising a HCDR1 region comprising the amino acid sequence of SEQ ID NO: 20, a HCDR2 region comprising the amino acid sequence of SEQ ID NO: 21, a HCDR3 region comprising the amino acid sequence of SEQ ID NO: 22; or
iv) an antibody V L comprising a LCDR1 region comprising the amino acid sequence of SEQ ID NO: 26, a LCDR2 region comprising the amino acid sequence of SEQ ID NO: 27 and a LCDR3 region comprising the amino acid sequence of SEQ ID NO: 28.
11. A vector comprising at least one nucleic acid according to claim 10 .
12. A host cell comprising at least one vector according to claim 11 .
13. A nucleic acid encoding:
i) an antibody V H comprising the amino acid sequence of SEQ ID NO:17;
ii) an antibody V L comprising the amino acid sequence of SEQ ID NO:16;
iii) an antibody V H comprising the amino acid sequence of SEQ ID NO:30; or
iv) an antibody V L comprising the amino acid sequence of SEQ ID NO:29.
14. A vector comprising at least one nucleic acid according to claim 13 .
15. A host cell comprising at least one vector according to claim 14 .
16. The nucleic acid according to claim 13 , comprising the nucleic acid sequence set forth as SEQ ID NO:18-19, SEQ ID NO:44-45, SEQ ID NO:67-70, SEQ ID NO:31-32, SEQ ID NO:57, or SEQ ID NO:71.
17. A vector comprising at least one nucleic acid according to claim 16 .
18. A host cell comprising at least one vector according to claim 17 .