Methods and systems to diagnose depression

1. A method comprising:

receiving sensor data at a processor from one or more sensors of a medical device, wherein the sensor data corresponds to at least a first body parameter value for a patient and a second body parameter value for the patient;

determining, via the processor, a first depression-indicative value based on the first body parameter value and a second depression-indicative value based on the second body parameter value;

determining, via the processor, a first weight and a second weight;

determining, via the processor, a depression detection value as a function of, in part, the first weight applied to the first depression-indicative value and the second weight applied to the second depression-indicative value;

determining, via the processor, a depression state based at least in part on a comparison of the depression detection value to a first threshold value and a second threshold value different from the first threshold value, the first threshold value associated with an onset of a depression episode, the second threshold value associated with an offset of the depression episode; and

in response to determining that the depression state indicates depression onset, initiating, via the processor, neurostimulation therapy by one or more electrodes.

2. The method of claim 1 , further comprising automatically adjusting, via the processor, at least one of the first weight or the second weight in response to an indication contradicting the depression state.

3. The method of claim 2 , wherein the indication is included in depression data, the depression data comprising at least one of patient input data, historic data corresponding to values as a function of time, or second sensor data from one or more sensors.

4. The method of claim 1 , wherein the neurostimulation therapy initiated in response to determining that the depression state indicates depression onset is a closed-loop therapy.

5. The method of claim 4 , wherein the closed-loop therapy comprises cranial nerve stimulation (CNS), and wherein the CNS comprises external trigeminal nerve stimulation (TNS), vagus nerve stimulation (VNS), or a combination thereof.

6. The method of claim 1 , further comprising adjusting, via the processor, the first weight based on a state of current physical activity of the patient relating to a current level of exercise of the patient.

7. The method of claim 6 , wherein the state of activity comprises one or more of an awake state, a resting state, a sleeping state, or an exercise state.

8. The method of claim 1 , further comprising setting, via the processor, an initial value of the first weight and an initial value of the second weight based on an input from a health care provider, based on the sensor data, based on historic data, or based on a selected patient population.

9. The method of claim 1 , wherein determining the first depression-indicative value comprises calculating, via the processor, the first depression-indicative value as a ratio of a first moving average value of the first body parameter value over a first time period to a second moving average value of the first body parameter value over a second time period.

10. The method of claim 1 , wherein the first body parameter value is a skin temperature, skin conductance, heart rate, change in heart rate, blood oxygen saturation, acceleration, respiration rate, or a value determined as a combination thereof.

11. The method of claim 1 , further comprising:

comparing, via the processor, a trend of one or more body parameter values as a function of time to at least one trend threshold; and

outputting, via the processor, a recommendation when the trend satisfies at least one trend threshold, wherein the recommendation is associated with a prompt to take one or more actions to inhibit a depression episode in the patient.

12. A system comprising:

a processing unit comprising a processor and a memory storing instructions that are executable by the processor to:

receive first sensor data corresponding to a first body parameter value for a patient from a first sensor;

receive second sensor data corresponding to a second body parameter value for the patient from a second sensor;

determine a first depression-indicative value based on the first body parameter value and determine a second depression-indicative value based on the second body parameter value;

determine a first weight and a second weight;

determine a depression detection value as a function of, in part, the first weight applied to the first depression-indicative value and the second weight applied to the second depression-indicative value;

determine a depression state based at least in part on a comparison of the depression detection value to a first threshold value and a second threshold value different from the first threshold value, the first threshold value associated with an onset of a depression episode, the second threshold value associated with an offset of the depression episode; and

in response to determining that the depression state indicates depression onset, initiate neurostimulation therapy by one or more electrodes.

13. The system of claim 12 , wherein the instructions are further executable by the processor to adjust at least one of the first weight or the second weight in response to an indication contradicting the depression state.

14. The system of claim 12 , wherein the neurostimulation therapy initiated in response to determining that the depression state indicates depression onset is a closed-loop therapy.

15. The system of claim 12 , wherein the instructions are further executable by the processor to adjust the first weight based on a state of current physical activity of the patient relating to a current level of exercise of the patient.

16. The system of claim 15 , wherein the state of activity includes one or more of an awake state, a resting state, a sleeping state, or an exercise state.

17. The system of claim 12 , wherein the first body parameter value is skin temperature, skin conductance, heart rate, change in heart rate, blood oxygen saturation, acceleration, respiration rate, or a value determined as a combination thereof.

18. A non-transitory computer-readable medium comprising instructions executable by a processor to:

determine a first depression-indicative value based on a first body parameter value for a patient and a second depression-indicative value based on a second body parameter value for the patient;

determine a first weight and a second weight;

determine a depression detection value based in part on the first weight and the first depression-indicative value and based in part on the second weight and the second weight and the second depression-indicative value;

determine a depression state based at least in part on a comparison of the depression detection value to a first threshold value and a second threshold value different from the first threshold value, the first threshold value associated with an onset of a depression episode, the second threshold value associated with an offset of the depression episode; and

in response to determining that the depression state indicates depression onset, initiate neurostimulation therapy by one or more electrodes.

19. The non-transitory computer-readable medium of claim 18 , further comprising instructions executable by the processor to perform at least one of:

adjusting the first weight based on a current state of physical activity of the patient relating to a current level of exercise of the patient; or

adjusting at least one of a first set of rules used to determine the first weight or a second set of rules used to determine the second weight based on sensor data for the patient that indicates depression onsets and offsets.

20. The non-transitory computer-readable medium of claim 18 , wherein the neurostimulation therapy initiated in response to determining that the depression state indicates depression onset is a closed-loop therapy.