Tableted chewing gum with enhanced delivery of cannabinoids

1. A method of oral administration of cannabinoids in a tableted chewing gum composition comprising water-soluble chewing gum ingredients and water-insoluble gum base located in a plurality of particles, and

one or more cannabinoids, the method comprising the steps of:

i) premixing the one or more cannabinoids with one or more carriers to obtain a uniform premixture, the one or more carriers comprising one or more sugar alcohol carries or one or more sugar carriers, with the proviso that the one or more carriers do not limit free transfer and release of the one or more cannabinoids in a chewing gum formulation;

ii) blending the uniform premixture with at least a part of the plurality of particles to obtain a flowable mixture for tableting;

iii) pressing the flowable mixture for tableting in a direct compression apparatus by means of punches to obtain a tableted chewing gum composition with reduced bulk volume and formation of bonds between at least a part of the plurality of particles; and

iv) subjecting the tableted chewing gum composition to a person in need thereof, whereby the chewing gum composition generates saliva and delivers more than 20% by weight and less than 60% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing,

the delivery of the one or more cannabinoids being estimated by measuring the content of the one or more cannabinoids in saliva collected during and after the 5 minutes of chewing and generated at a chewing frequency of 60 chews each minute without swallowing saliva during the 5 minutes of chewing and measuring the content of the one or more cannabinoids in the remaining chewing gum residue.

2. The method according to claim 1 , wherein the chewing gum composition delivers more than 30% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing.

3. The method according to claim 1 , wherein the plurality of particles includes a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients.

4. The method according to claim 3 , wherein the first population of particles is present in an amount of 20 to 60% by weight of the tableted chewing gum composition.

5. The method according to claim 3 , wherein the second population of particles is present in an amount of 40 to 80% by weight of the tableted chewing gum composition.

6. The method according to claim 3 , wherein the content of water-insoluble gum base of the first population of particles is more than 30% by weight of the first population of particles.

7. The method according to claim 3 , wherein the content of water-soluble chewing gum ingredients of the second population of particles is more than 50% by weight of the second population of particles, the second population of particles being free of water-insoluble gum base.

8. The method according to claim 3 , wherein the one or more cannabinoids is present in the second population of particles comprising water-soluble chewing gum ingredients.

9. The method according to claim 1 , wherein the water-insoluble gum base is partly located in a first layer of the chewing gum composition and the water-soluble chewing gum ingredients are partly located in a second layer of the chewing gum composition together with the one or more cannabinoids.

10. The method according to claim 1 , wherein the water-insoluble gum base is located in a first layer of the chewing gum composition and the water-soluble chewing gum ingredients are partly located in a second layer of the chewing gum composition together with the one or more cannabinoids.

11. The method according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), salts thereof, and derivatives thereof.

12. The method according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), salts thereof, and derivatives thereof.

13. The method according to claim 1 , wherein the one or more cannabinoids comprises at least one phytocannabinoid that forms part of an extract when formulated in the tableted chewing gum.

14. The method according to claim 1 , wherein the chewing gum further comprises terpenes.

15. The method according to claim 1 , wherein the one or more cannabinoids comprises at least one isolated cannabinoid.

16. The method according to claim 1 , wherein the one or more cannabinoids comprises at least one water-soluble cannabinoid.

17. The method according to claim 1 , wherein the chewing gum comprises one or more emulsifiers.

18. The method according to claim 1 , wherein the chewing gum comprises one or more solubilizers.

19. The method according to claim 1 , wherein the chewing gum comprises a self-emulsifying agent.

20. The method according to claim 1 , wherein the premixture comprises a lipid carrier for the one or more cannabinoids.

21. A method of alleviating or treating a medical condition comprising administering a method of oral administration according to claim 1 .

22. The method according to claim 1 , wherein the water-soluble chewing gum ingredients comprise one or more sugar alcohols in an amount of 35-80% by weight of the tableted chewing gum composition, or

one or more sugars in an amount of 35-80% by weight of the tableted chewing gum composition.

23. The method according to claim 1 , wherein the water-soluble chewing gum ingredients comprise:

one or more sugar alcohols selected from the group consisting of xylitol, sorbitol, mannitol, maltitol, isomaltitol, isomalt, erythritol, lactitol, maltodextrin, and

combinations thereof, in an amount of 35-80% by weight of the tableted chewing gum composition, or

one or more sugars selected from the group consisting of dextrose, sucrose, maltose, fructose, lactose, and combinations thereof, in an amount of 35-80% by weight of the tableted chewing gum composition.

24. A method of oral administration of cannabinoids in a tableted chewing gum composition comprising water-soluble chewing gum ingredients and water-insoluble gum base located in a plurality of particles, and

one or more cannabinoids, the method comprising the step of:

i) premixing the one or more cannabinoids with one or more carriers to obtain a uniform premixture, the one or more carriers comprising one or more sugar alcohol carriers or one or more sugar carriers, with the proviso that the one or more carriers do not include polymer carriers;

ii) blending the uniform premixture with at least a part of the plurality of particles to obtain a flowable mixture for tableting;

iii) pressing the flowable mixture for tableting in a direct compression apparatus by means of punches to obtain a compact coherent tablet without a brittle structure in the initial chew; and

iv) subjecting the tableted chewing gum composition to a person in need thereof, whereby the chewing gum composition generates saliva and delivers more than 20% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing,

the delivery of the one or more cannabinoids being estimated by measuring the content of the one or more cannabinoids in saliva collected during and after the 5 minutes of chewing and generated at a chewing frequency of 60 chews each minute without swallowing saliva during the 5 minutes of chewing and measuring the content of the one or more cannabinoids in the remaining chewing gum residue.

25. A method of oral administration of cannabinoids in a tableted chewing gum composition comprising water-soluble chewing gum ingredients and water-insoluble gum base located in a plurality of particles, and

one or more cannabinoids, the method comprising the steps of:

i) premixing the one or more cannabinoids with one or more carriers to obtain a uniform premixture, the one or more carriers comprising one or more sugar alcohol carriers, one or more sugar carriers or one or more microcrystalline cellulose species;

ii) blending the uniform premixture with at least a part of the plurality of particles to obtain a flowable mixture for tableting;

iii) pressing the flowable mixture for tableting in a direct compression apparatus by means of punches to obtain a tableted chewing gum composition with reduced bulk volume and formation of bonds between at least a part of the plurality of particles; and

iv) subjecting the tableted chewing gum composition to a person in need thereof, whereby the chewing gum composition generates saliva and delivers more than 20% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing,

the delivery of the one or more cannabinoids being estimated by measuring the content of the one or more cannabinoids in saliva collected during and after the 5 minutes of chewing and generated at a chewing frequency of 60 chews each minute without swallowing saliva during the 5 minutes of chewing and measuring the content of the one or more cannabinoids in the remaining chewing gum residue.

26. A method of oral administration of cannabinoids in a tableted chewing gum composition comprising water-soluble chewing gum ingredients and water-insoluble gum base located in a plurality of particles, and

one or more cannabinoids, the method comprising the steps of:

i) premixing the one or more cannabinoids with one or more carriers to obtain a uniform premixture, the one or more carriers comprising a lipid carrier for the one or more cannabinoids;

ii) blending the uniform premixture with at least a part of the plurality of particles to obtain a flowable mixture for tableting;

iii) pressing the flowable mixture for tableting in a direct compression apparatus by means of punches to obtain a tableted chewing gum composition with reduced bulk volume without a crumbling structure in the initial chew; and

iv) subjecting the tableted chewing gum composition to a person in need thereof, whereby the chewing gum composition generates saliva and delivers more than 20% by weight and less than 60% by weight of the one or more cannabinoids to the oral mucosa during the first 5 minutes of chewing,

the delivery of the one or more cannabinoids being estimated by measuring the content of the one or more cannabinoids in saliva collected during and after the 5 minutes of chewing and generated at a chewing frequency of 60 chews each minute without swallowing saliva during the 5 minutes of chewing and measuring the content of the one or more cannabinoids in the remaining chewing gum residue.

27. The method according to claim 26 , wherein the one or more cannabinoids are present in an amount of 0.1 to 100 mg.

28. The method according to claim 26 , wherein the one or more cannabinoids are present in an amount of 0.1 to 50 mg.

29. The method according to claim 26 , wherein the one or more cannabinoids are present in an amount of 0.1 to 30 mg.