Extracts of
The invention provides a method for extracting active therapeutic components from plant materials of the cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.
1. A pharmaceutical composition for lowering serum cholesterol comprising an effective amount of a solid-form Cyclanthera Pedata extract and a pharmaceutically acceptable carrier, wherein the extract is obtained by the steps of:
(a) immersing fresh fruit from a Cyclanthera Pedata plant in an aqueous solution containing peracetic acid for a period of time of about 2 minutes to 10 minutes,
(b) cutting the fruit into strips and removing the seeds and mucilage from said strips,
(c) drying the seedless strips at a temperature between 10° C. and 80° C.,
(d) milling the dried strips to produce particles having a size of about 2-10 mm,
(e) extracting the milled particles by immersing them in ethanol and performing an extraction process selected from the group consisting of: maceration, ultrasound-assisted extraction, microwave-assisted extraction, percolation, Soxhlet extraction, pressurized solvent extraction, extraction under reflux, countercurrent extraction and steam distillation, for a period of time of about 30 minutes to about 15 days to obtain a liquid extract,
(f) concentrating the liquid extract from step (e) to between 20% to 80% solids, and
(g) absorbing the concentrated extract in a microcrystalline cellulose matrix to yield the Cyclanthera Pedata in solid form.
2. The pharmaceutical composition of claim 1 further comprising an omega oil from marine sources with concentration EPA/DHA between 30 and 95%.