BONE GROWTH FACILITATION DEVICE AND METHODS OF USE
The instant disclosure is directed to devices and methods for facilitating bone growth. In one embodiment, a device may include a porous flexible tube comprising an electrospun fiber. The porous flexible tube may also comprise a closed end. The device may further comprise a filler material at least partially encased by the porous flexible tube. A method of manufacturing such a device may comprise electrospinning a polymer solution onto an end of a cylindrical mandrel to form the porous flexible tube, and removing the porous flexible tube from the end of the cylindrical mandrel. A method of facilitating bone growth may comprise obtaining such a device, and implanting the porous flexible tube into a subject's bone defect.
1 . A device for facilitating bone growth, the device comprising:
a porous flexible tube comprising an electrospun polymer fiber.
2 . The device of claim 1 , wherein the porous flexible tube comprises at least one closed end.
3 . The device of claim 2 , further comprising a filler material at least partially encased by the porous flexible tube.
4 . The device of claim 3 , wherein the filler material comprises a bone graft material selected from the group consisting of autologous bone, allogeneic bone, human cadaver bone, demineralized bone, xenograft bone, hydroxyapatite, tricalcium phosphate, bioactive glass, a growth factor, particles thereof, and combinations thereof.
5 . The device of claim 1 , wherein the electrospun polymer fiber comprises co-electrospun fibers selected from the group consisting of polyglycolide fibers, polycaprolactone fibers, and polylactide-co-caprolactone fibers.
6 . The device of claim 1 , wherein the electrospun polymer fiber further comprises an additional material selected from the group consisting of an antibiotic, a growth factor, a vitamin, a cytokine, a protein, and combinations thereof.
7 . The device of claim 1 , wherein the porous flexible tube comprises pores having a diameter of about 5 μm to about 50 μm, and wherein the porous flexible tube comprises an inner diameter of about 5 mm to about 20 mm.
8 . A method of manufacturing a device for facilitating bone growth, the method comprising:
electrospinning a polymer solution onto a cylindrical mandrel to form a porous flexible tube comprising an electrospun polymer fiber; and
removing the porous flexible tube from the cylindrical mandrel.
9 . The method of claim 8 , wherein electrospinning comprises electrospinning the polymer solution onto an end of the cylindrical mandrel, and wherein the porous flexible tube comprises at least one closed end.
10 . The method of claim 9 , further comprising at least partially encasing a filler material within the porous flexible tube.
11 . The method of claim 10 , wherein the filler material comprises a bone graft material selected from the group consisting of autologous bone, allogeneic bone, human cadaver bone, demineralized bone, xenograft bone, hydroxyapatite, tricalcium phosphate, bioactive glass, a growth factor, particles thereof, and combinations thereof.
12 . The method of claim 8 , wherein the electrospun polymer fiber further comprises an additional material selected from the group consisting of an antibiotic, a growth factor, a vitamin, a cytokine, a protein, and combinations thereof.
13 . The method of claim 8 , wherein the porous flexible tube comprises pores having a diameter of about 5 μm to about 50 μm, and wherein the porous flexible tube comprises an inner diameter of about 5 mm to about 20 mm.
14 . A method of facilitating bone growth, the method comprising:
obtaining a porous flexible tube comprising an electrospun polymer fiber; and
implanting the porous flexible tube into a bone defect of a subject.
15 . The method of claim 14 , wherein the porous flexible tube comprises at least one closed end.
16 . The method of claim 15 , further comprising at least partially encasing a filler material within the porous flexible tube.
17 . The method of claim 16 , wherein the filler material comprises a bone graft material selected from the group consisting of autologous bone, allogeneic bone, human cadaver bone, demineralized bone, xenograft bone, hydroxyapatite, tricalcium phosphate, bioactive glass, a growth factor, particles thereof, and combinations thereof.
18 . The method of claim 14 , wherein the electrospun polymer fiber further comprises an additional material selected from the group consisting of an antibiotic, a growth factor, a vitamin, a cytokine, a protein, and combinations thereof.
19 . The method of claim 14 , wherein the porous flexible tube comprises pores having a diameter of about 5 μm to about 50 μm, and wherein the porous flexible tube comprises an inner diameter of about 5 mm to about 20 mm.
20 . The method of claim 14 , wherein implanting the porous flexible tube into the bone defect of the subject comprises placing the porous flexible tube in contact with a portion of the bone defect.