Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry

1. A method of preventing or treating an infestations of a laying hen by a temporary parasitic arthropod comprising administering via the drinking water an effective amount of an isoxazoline compound of formula (I)

Wherein

R 1 =halogen, CF 3 , OCF 3 , CN,

n=integer from 0 to 3

R 2 =C 1 -C 3 -haloalkyl

T=5- or 6-membered ring, which is optionally substituted by one or more radicals Y,

or is selected from

wherein in T-1, T-3 and T-4 the radical Y is hydrogen, halogen, methyl, halomethyl, ethyl, haloethyl;

Y=methyl, halomethyl, halogen, CN, NO 2 , NH 2 —C═S, or two adjacent radicals Y form together a chain;

Q=X—NR 3 R 4 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals;

X=CH 2 , CH(CH 3 ), CH(CN), CO, CS,

R 3 =hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl,methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethylaminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl,

wherein Z A =hydrogen, halogen, cyano, halomethyl (CF 3 );

R 4 =hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propylcarbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarbonylethyl;

or R 3 and R 4 together form a substituent selected from the group consisting of:

or a salt or solvate thereof;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two or three separate dosages approximately 7 days apart;

wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus spp. and/or Ornithonyssus spp. mites; and

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

2. The method according to claim 1 wherein the isoxazoline compound is afoxolaner or lotilaner.

3. The method of claim 1 wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus gallinae.

4. The method according to claim 1 wherein the isoxazoline compound is administered in two separate dosages approximately 7 days apart.

5. The method according to claim 1 wherein the isoxazoline compound is administered in three separate dosages approximately 7 days apart.

6. A method for the prevention or treatment of parasitic arthropod infestations of laying hens during the laying period comprising administering via drinking water an effective amount of an isoxazoline compound of formula (I)

Wherein

R 1 =halogen, CF 3 , OCF 3 , CN,

n=integer from 0 to 3,

R 2 =C 1 -C 3 -haloalkyl,

T=5- or 6-membered ring, which is optionally substituted by one or more radicals Y,

or is selected from

wherein in T-1, T-3 and T-4 the radical Y is hydrogen, halogen, methyl, halomethyl, ethyl, haloethyl;

Y=methyl, halomethyl, halogen, CN, NO 2 , NH 2 —C═S, or two adjacent radicals Y form together a chain;

Q=X—NR 3 R 4 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals;

X=CH 2 , CH(CH 3 ), CH(CN), CO, CS,

R 3 =hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl,methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonyl ethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethyl aminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl,

wherein Z A =hydrogen, halogen, cyano, halomethyl (CF 3 );

R 4 =hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propyl carbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarbonyl ethyl;

or R 3 and R 4 together form a substituent selected from the group consisting of:

or a salt or solvate thereof, and a pharmaceutically acceptable carrier;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two or three separate dosages approximately 7 days apart;

wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus spp. and/or Ornithonyssus spp. mites; and

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

7. A Method of controlling darkling beetles in the environment of poultry animals comprising administering to the poultry animal via drinking water an effective amount of an isoxazoline compound of formula (I)

Wherein

R 1 =halogen, CF 3 , OCF 3 , CN,

n=integer from 0 to 3,

R 2 =C 1 -C 3 -haloalkyl,

T=5- or 6-membered ring, which is optionally substituted by one or more radicals Y,

or is selected from

wherein in T-1, T-3 and T-4 the radical Y is hydrogen, halogen, methyl, halomethyl, ethyl, haloethyl;

Y=methyl, halomethyl, halogen, CN, NO 2 , NH 2 —C═S, or two adjacent radicals Y form together a chain;

Q=X—NR 3 R 4 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals;

X=CH 2 , CH(CH 3 ), CH(CN), CO, CS,

R 3 =hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl,methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonyl ethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethyl aminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl,

wherein Z A =hydrogen, halogen, cyano, halomethyl (CF 3 );

R 4 =hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxym ethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propyl carbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarb onylm ethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarb onyl ethyl;

or R 3 and R 4 together form a substituent selected from the group consisting of:

or a salt or solvate thereof;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two or three separate dosages approximately 7 days apart; and

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

8. The method according to claim 7 wherein the isoxazoline compound is afoxolaner or lotilaner.

9. The method according to claim 6 wherein the isoxazoline compound is afoxolaner or lotilaner.

10. The method of claim 1 , wherein n is 1, 2 or 3.

11. The method of claim 1 , wherein R 2 is CF 3 or CF 2 Cl.

12. The method of claim 1 , wherein two adjacent radicals Y form together a three or four member chain.

13. The method according to claim 6 , wherein n is 1, 2 or 3.

14. The method according to claim 6 , wherein R 2 is CF 3 or CF 2 Cl.

15. The method according to claim 6 , wherein two adjacent radicals Y form together a three or four member chain.

16. The method according to claim 7 , wherein n is 1, 2 or 3.

17. The method according to claim 7 , wherein R 2 is CF 3 or CF 2 Cl.

18. The method according to claim 7 , wherein two adjacent radicals Y form together a three or four member chain.

19. A method of preventing or treating an infestations of a laying hen by a temporary parasitic arthropod comprising administering via the drinking water an effective amount of an isoxazoline compound, wherein the isoxazoline compound is sarolaner or a salt or solvate thereof;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two separate dosages approximately 7 days apart;

wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus spp. and/or Ornithonyssus spp. mites; and

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

20. A method for the prevention or treatment of parasitic arthropod infestations of laying hens during the laying period comprising administering via drinking water an effective amount of an isoxazoline compound, wherein the isoxazoline compound is sarolaner or a salt or solvate thereof;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two separate dosages approximately 7 days apart;

wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus spp. and/or Ornithonyssus spp. mites; and

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

21. A Method of controlling darkling beetles in the environment of poultry animals comprising administering to the poultry animal via drinking water an effective amount of an isoxazoline compound, wherein the isoxazoline compound is sarolaner or a salt or solvate thereof;

wherein the effective dose of the isoxazoline compound is administered via the drinking water in two separate dosages approximately 7 days apart;

wherein the effective amount is between 0.1 and 10 mg/kg body weight of animals treated.

22. The method according to claim 6 wherein the isoxazoline compound is administered in two separate dosages approximately 7 days apart.

23. The method according to claim 6 wherein the isoxazoline compound is administered in three separate dosages approximately 7 days apart.

24. The method according to claim 7 wherein the isoxazoline compound is administered in two separate dosages approximately 7 days apart.

25. The method according to claim 7 wherein the isoxazoline compound is administered in three separate dosages approximately 7 days apart.