IP Library Granted Patent US 11,457,855
Granted Patent B2
US 11,457,855 · App. 16/294,917 · Granted Oct 4, 2022

Method and system for utilizing empirical null hypothesis for a biological time series

Inventors: Scott B. Wilson (Del Mar, CA); Mark L. Scheuer (Wexford, PA)
Assignee: Persyst Development Corporation
A61B5/374A61B5/316A61B5/7267
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,457,855
App. No.
16/294,917
Granted
Oct 4, 2022
Kind
B2
Abstract

A method and system for utilizing empirical null hypothesis for a biological time series is disclosed herein. The method also includes calculating an amount that a second plurality of epochs is similar to a first plurality of epochs using large-scale testing to estimate an empirical null hypothesis for a subset of the epochs. The method also includes determining if the second plurality of epochs is from the same EEG recording.

Claims (14)

1. A method for determining if a first section of a biological time series is comparable to a second section of a biological time series, the method comprising:

selecting, at a processor, a first section of a biological time series based on a plurality of digital signals generated from a source;

establishing, at the processor, the first section as a baseline section, wherein the processor comprises a computer readable medium and an empirical null hypothesis engine that outputs an empirical null hypothesis;

selecting, at the processor, a second section of the biological time series for measurement;

calibrating and validating a raw score processed through filters and neural network algorithms, wherein said calibrating and validating is based on the empirical null hypothesis, to provide a probability score of an event for the biological time series;

determining, at the processor, a similarity of the second section to the baseline section using the empirical null hypothesis in an empirical examination of data for a subset of the biological time series to validate the probability score of an event for the biological time series; and

generating, at a processor, a Z-score expressing a difference from a baseline that is displayed in a time series on a display device to show how a derived value is varying from the baseline over time, wherein the display device is at least one of a mobile phone, a PDA, a computer, or a TV screen.

2. An EEG system, the EEG system comprising: a processor comprising a computer readable medium and an empirical null hypothesis engine that outputs an empirical null hypothesis, wherein the computer readable medium includes instructions executable by the processor to:

calibrate and validate a raw score processed through artifact reduction filters and neural network algorithms, wherein said calibrating and validating is based on the empirical null hypothesis, to provide a probability score of a seizure event;

select a first epoch of an EEG recording;

establish the first epoch as a baseline epoch;

select a second epoch of the EEG recording for measurement;

determine a similarity of the second epoch to the baseline epoch using the empirical null hypothesis in an empirical examination of data for a subset of the epochs to validate the probability score of a seizure event; and

generate a Z-score expressing a difference from a baseline that is displayed in a time series on a display device to show how a derived value is varying from the baseline over time, wherein the display device is at least one of a mobile phone, a PDA, a computer, or a TV screen.

Assignments (2)
CHANGE OF NAME Recorded Dec 11, 2024
From: PERSYST DEVELOPMENT CORPORATION
To: PERSYST DEVELOPMENT LLC
Reel/Frame 069603/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2019
From: WILSON, SCOTT B.; SCHEUER, MARK L., DR.
To: PERSYST DEVELOPMENT CORPORATION
Reel/Frame 048853/0087 →