Benzoimidazoles as prolyl hydroxylase inhibitors
The present invention is directed to benzoimidazole compounds of the formula: and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.
1. A compound having PHD inhibitor activity of the formula (I):
wherein:
n is 2-4;
each R 1 is independently selected from H, halo, —C 1-4 perhaloalkyl, trifluoroC 1-4 -alkoxy, and —SC 1-4 alkyl;
R 2 and R 3 are both H, —CF 3 , or C 1-3 alkyl;
each Z is C; or an enantiomer, a diastereomer, a racemate, or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein R 2 and R 3 are both H.
3. The compound according to claim 1 , wherein R 2 and R 3 are both —CF 3 .
4. The compound according to claim 1 , wherein R 2 and R 3 are both C 1-3 alkyl.