SYSTEMS AND METHODS FOR TREATMENT-EFFECT ANALYSIS
Systems and computer-implemented methods for analysis of medical literature to assemble synthetic cohorts are provided. In various embodiments, a plurality of literature sources relating to a medical condition are retrieved. The plurality of literature sources comprise published observational studies. A first plurality of features is extracted from the plurality of literature sources. A subpopulation is defined based on the first plurality of features. An effectiveness of a treatment within the subpopulation is predicted based on the plurality of features. A plurality of electronic medical records is retrieved. The effectiveness of the treatment is validated against the plurality of electronic medical records.
1 . A computer-implemented method comprising:
retrieving a plurality of literature sources relating to a medical condition, the plurality of literature sources comprising published observational studies;
extracting a first plurality of features from the plurality of literature sources;
defining a subpopulation based on the first plurality of features;
predicting an effectiveness of a treatment within the subpopulation based on the plurality of features;
retrieving a plurality of electronic medical records;
validating the effectiveness of the treatment against the plurality of electronic medical records.
2 . The method of claim 1 , wherein the electronic medical records comprise health data, insurance claim data, or registry data.
3 . The method of claim 1 , wherein the first plurality of features comprises disease definition, condition definition, outcome, standard of care, treatment, effectiveness, cohort definition, inclusion criteria, exclusion criteria, primary endpoint, secondary endpoint, potential modifier, one or more confounders, minimum sample size, or study duration.
4 . The method of claim 1 , wherein predicting the effectiveness comprises applying a trained model to features of the subpopulation.
5 . The method of claim 4 , wherein the model comprises an ensemble model.
6 . The method of claim 1 , wherein extracting the first plurality of features comprises applying natural language processing to the plurality of literature sources.
7 . The method of claim 1 , wherein validating the effectiveness of the treatment comprises determining a second plurality of features of the plurality of electronic medical records and comparing the effectiveness against those of the plurality of electronic medical records correlated with the first plurality of features.
8 . A system comprising:
a computing node comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor of the computing node to cause the processor to perform a method comprising:
retrieving a plurality of literature sources relating to a medical condition, the plurality of literature sources comprising published observational studies;
extracting a first plurality of features from the plurality of literature sources;
defining a subpopulation based on the first plurality of features;
predicting an effectiveness of a treatment within the subpopulation based on the plurality of features;
retrieving a plurality of electronic medical records;
validating the effectiveness of the treatment against the plurality of electronic medical records.
9 . The system of claim 8 , wherein the electronic medical records comprise health data, insurance claim data, or registry data.
10 . The system of claim 8 , wherein the first plurality of features comprises disease definition, condition definition, outcome, standard of care, treatment, effectiveness, cohort definition, inclusion criteria, exclusion criteria, primary endpoint, secondary endpoint, potential modifier, one or more confounders, minimum sample size, or study duration.
11 . The system of claim 8 , wherein predicting the effectiveness comprises applying a trained model to features of the subpopulation.
12 . The system of claim 11 , wherein the model comprises an ensemble model.
13 . The system of claim 8 , wherein extracting the first plurality of features comprises applying natural language processing to the plurality of literature sources.
14 . The system of claim 8 , wherein validating the effectiveness of the treatment comprises determining a second plurality of features of the plurality of electronic medical records and comparing the effectiveness against those of the plurality of electronic medical records correlated with the first plurality of features.
15 . A computer program product for treatment-effect analysis, the computer program product comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to perform a method comprising:
retrieving a plurality of literature sources relating to a medical condition, the plurality of literature sources comprising published observational studies;
extracting a first plurality of features from the plurality of literature sources;
defining a subpopulation based on the first plurality of features;
predicting an effectiveness of a treatment within the subpopulation based on the plurality of features;
retrieving a plurality of electronic medical records;
validating the effectiveness of the treatment against the plurality of electronic medical records.
16 . The computer program product of claim 15 , wherein the electronic medical records comprise health data, insurance claim data, or registry data.
17 . The computer program product of claim 15 , wherein the first plurality of features comprises disease definition, condition definition, outcome, standard of care, treatment, effectiveness, cohort definition, inclusion criteria, exclusion criteria, primary endpoint, secondary endpoint, potential modifier, one or more confounders, minimum sample size, or study duration.
18 . The computer program product of claim 15 , wherein predicting the effectiveness comprises applying a trained model to features of the subpopulation.
19 . The computer program product of claim 18 , wherein the model comprises an ensemble model.
20 . The computer program product of claim 15 , wherein validating the effectiveness of the treatment comprises determining a second plurality of features of the plurality of electronic medical records and comparing the effectiveness against those of the plurality of electronic medical records correlated with the first plurality of features.