Bone putty for bone pore and void filling
A bone pore or void filling composition is described. The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; a bone growth stimulator; and bioactive glass. A kit for containing the bone pore or void filling composition, and methods for using the composition to fill a bone pore or void are also described.
1. A bone pore or void filling composition, comprising a mixture of:
a collagen component comprising a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate;
a polyethylene glycol component comprising a blend of polyethylene glycol polymers having different molecular weights, wherein the blend of the polyethylene glycol polymers comprises 55% to 90% by weight of the composition;
a calcium phosphate component comprising tricalcium phosphate; and
a glass component comprising bioactive glass,
wherein the blend of polyethylene glycol polymers comprises a first polyethylene glycol polymer having a molecular weight within the range of 1350 g/mol to 1650 g/mol and a second polyethylene glycol polymer having a molecular weight within the range of 350 g/mol to 650 g/mol, the bioactive glass comprises from 3% to 7.5% by weight of the composition, the tricalcium phosphate comprises from 15% to 30% by weight of the composition, and the weight percent of the type I collagen or the type I collagen-glycosaminoglycan coprecipitate ranges from 0.2% to 1.5% relative to the total weight of the composition.
2. The composition of claim 1 , wherein the tricalcium phosphate and the bioactive glass in the mixture comprise particles dimensioned to fill the bone pores.
3. The composition of claim 1 , wherein the collagen component is milled through a screen mesh prior to including in the mixture.
4. The composition of claim 1 , wherein all components of the mixture are configured to fill bone pores of a size less than 600 microns.
5. The composition of claim 1 , wherein the bone pore filling composition comprises a type I collagen.
6. The composition of claim 1 , wherein the bone pore filling composition comprises a type I collagen-glycosaminoglycan coprecipitate.
7. The composition of claim 1 , wherein the composition further comprises a hemostatic agent.
8. A method of filling a bone pore or void, comprising administering a composition according to claim 1 to the site of the bone pore or void.
9. The method of claim 8 , wherein the composition is applied to the bone pore or void by an individual.
10. The method of claim 8 , wherein the composition is injected into the bone pore or void using a syringe.
11. The method of claim 8 , wherein the bone pore has a diameter from 75 microns to 350 microns.
12. The method of claim 8 , wherein the composition is applied to a bone pore in spongy bone.
13. The method of claim 8 , wherein the composition is applied to at least one of a natural bone void or a surgically created void.
14. A bone pore or void filling kit, comprising:
the bone pore or void filling composition of claim 1 ;
a syringe for administering the composition; and
a sterile package for holding the composition and the syringe.
15. The kit of claim 14 , further comprising instructions for filling a bone pore.