Therapeutic dental pastes and related methods and kits

1. A dental paste comprising:

(i) a compound of Formula I:

wherein:

R 1 is a C 1 -C 2 alkyl group, and

R 2 is C(O)R 3 , wherein R 3 is a C 7 -C 9 alkyl group, and

n is 4;

(ii) a compound of Formula II or a pharmaceutically acceptable salt thereof:

wherein:

R 4 is a hydrogen atom or a C 1 -C 12 alkyl group, and

m is 4;

and (iii) a dental abrasive wherein the weight ratio of compound of Formula Ito compound of Formula II is 1:1.

2. The dental paste of claim 1 , wherein R 3 is a C 8 alkyl group.

3. The dental paste of claim 1 , wherein R 1 is a C 1 alkyl group; R 3 is a C 8 alkyl group; n is 4; R 4 is a hydrogen atom or a C 1 -C 8 alkyl group.

4. The dental paste of claim 1 , wherein the dental abrasive includes at least one of silica, alumina, perlite, pumice, calcium carbonate, calcium pyrophosphate, dicalcium phosphate, tricalcium phosphate, sodium bicarbonate, glycine, and a combination thereof.

5. The dental paste of claim 1 , further comprising a liquid carrier.

6. The dental paste of claim 5 , wherein the liquid carrier includes at least one of water, glycerin, propylene glycol, polyethylene glycol, and combinations thereof.

7. The dental paste of claim 1 , further comprising a fluoride source, an antibacterial agent, a surfactant, a thickener, a humectant, a buffering agent, a coloring agent, a pigment, a flavoring agent, a sweetener, a remineralizing agent, a desensitizing agent, a foaming agent, a therapeutic agent, an antigingivitis agent, and combinations thereof.

8. The dental paste of claim 1 , further comprising sorbitol in a concentration of at least 10 wt.-%, based on the total weight of the dental paste.

9. The dental paste of claim 1 , wherein the dental paste is a toothpaste.

10. The dental paste of claim 1 , wherein the dental paste is a prophy paste.

11. A method of treating a surface in the oral cavity of a subject, the method comprising:

(a) providing the dental paste of claim 1 ; and

(b) applying the dental paste to a surface in the oral cavity of the subject.

12. The method of claim 11 , wherein the surface is a hard surface.

13. The method of claim 11 , wherein the surface is a surface of a tooth.

14. The method of claim 11 , wherein applying the dental paste comprises brushing, swabbing, or a combination thereof.

15. A kit for treating a surface in the oral cavity of a subject, the kit comprising:

(a) the dental paste of claim 1 ; and

(b) an applicator.

16. The kit of claim 15 , wherein the applicator is selected from a brush, a swab, and a combination thereof.

17. A method of inhibiting biofilm formation on a surface in the oral cavity of a subject, the method comprising:

(a) providing the dental paste of claim 1 ; and

(b) applying the dental paste to a surface in the oral cavity of the subject.