Methods and kits of removing calculus
Methods and kids for removing calculus from a tooth. The method can include applying a component A comprising a hydrogen peroxide or a precursor thereto and a component B the comprising a catalase to the tooth, thereby generating oxygen; and removing at least a part of the calculus from the tooth.
1. A method of removing calculus from a tooth comprising:
providing a component A,
the component A comprising hydrogen peroxide or a hydrogen peroxide precursor;
providing a component B,
the component B comprises a catalase;
applying the component A and the component B to the tooth, thereby generating oxygen; and
removing at least a part of the calculus from the tooth,
wherein at least one of the component A and the component B is characterized by a viscosity of less than 26 Pa·s at a shear rate of 1/s at 25° C.
2. The method of claim 1 , wherein in the applying step, component A and component B are applied concurrently to the tooth.
3. The method of claim 1 , wherein prior to the applying step, component A and component B are mixed to form a mixture, and wherein in the applying step, the mixture is applied to the tooth.
4. The method of claim 1 , wherein in the applying step, component A and the component B are applied to the tooth for a time period less than 1 hour prior to the removing step.
5. The method of claim 1 , wherein the removing step occurs within 24 hours after the applying step.
6. The method of claim 1 , wherein the applying step and the removing step are completed in less than 1 hour.
7. The method of claim 1 , wherein the component A comprises at least about 0.003 M hydrogen peroxide.
8. The method of claim 1 , wherein the component A comprises from about 0.03 M to about 12 M hydrogen peroxide.
9. The method of claim 1 , wherein the component A comprises from about 0.1 M to about 3 M hydrogen peroxide.
10. The method of claim 1 , wherein the component B comprises greater than about 3 units/mL of catalase.
11. The method of claim 1 , wherein the component B comprises from about 30 units/mL to about 300,000 units/mL catalase.
12. The method of claim 1 , wherein the component B comprises from about 1,000 units/mL to about 20,000 units/mL catalase.
13. The method of claim 1 , wherein the component A and the component B are each characterized by a viscosity of less than 26 Pa·s at a shear rate of 1/s at 25° C.
14. The method of claim 1 , wherein the component A and the component B are each characterized by a viscosity of less than 16 Pa·s at a shear rate of 1/s at 25° C.
15. The method of claim 1 , wherein at least one of the component A and the component B is characterized by a viscosity of greater than 2 Pa·s at a shear rate of 1/s at 25° C.
16. The method of claim 1 , wherein the component A and the component B are each characterized a viscosity of greater than 2 Pa·s at a shear rate of 1/s at 25° C.
17. The method of claim 1 , wherein the hydrogen peroxide precursor is selected from the group consisting of carbamide peroxide, percarbonate salts or acids, polyvinylpyrrolidone (PVP) peroxide, and a combination thereof.
18. The method of claim 1 , wherein the hydrogen peroxide precursor is selected from the group consisting of perborate salts or acids, metal peroxides, organic peroxide, inorganic peroxyacids or salts, and a combination thereof.
19. The method of claim 1 , wherein the hydrogen peroxide precursor is an organic peroxide, and wherein the organic peroxide is a peracetate salt or acid.
20. The method of claim 1 , wherein the hydrogen peroxide precursor comprises a peroxide-generating enzyme.
21. The method of claim 1 , wherein at least one of the component A and the component B further comprising water, glycerol, a polyethylene glycol, a polyglycerol, or a combination thereof.
22. The method of claim 1 , wherein at least one of the component A and the component B further comprises a thickener.
23. The method of claim 22 , wherein the thickener is polyacrylic acid, gelatin, a polysaccharide, silica, or a combination thereof.
24. The method of claim 1 , wherein the removing step comprises removing by mechanical means.
25. The method of claim 1 , wherein the removing step at comprises removing by mechanical means other than tooth brushing.
26. The method of claim 1 , wherein the removing step comprises removing at least a part of the calculus from the tooth with a dental scaler.