Compounds and compositions for the treatment of cancer

1. A compound of formula (I):

wherein wherein X 1 is N and X 2 is C, and the ring N forms a double bond with X 2 ;

R 1 is aryl or substituted aryl;

R 2 is aryl or substituted aryl;

R 3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl;

R 4 is hydrogen, alkyl or substituted alkyl; and

R 5 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl;

or a salt, a hydrate, a solvate, or a stereoisomer thereof.

2. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 1 is substituted aryl.

3. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 2 is substituted aryl.

4. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 3 is C 1 -C 6 alkyl, heteroaryl or substituted heteroaryl.

5. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 4 is hydrogen.

6. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 4 is alkyl or substituted alkyl.

7. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 5 is substituted alkyl.

8. The compound of claim 7 , wherein R 5 is 5-hydroxy-4,4-dimethylpentyl; 5-hydroxy-5-methylhexyl; 3-methoxypropyl; 3-oxo-3-methoxypropyl; 2-methoxyethyl; 3-(dimethylamino)propyl; 4-methoxybutyl; 2-ethoxyethyl; 5-hydroxypentyl; 6-hydroxyhexyl; 4-hydroxybutyl; methyl acetate; (4-methylmorpholin-2-yl)methyl; (4-ethylmorpholin-2-yl)methyl; (4-cyclopropylmorpholin-2-yl)methyl; or (4-isopropylmorpholin-2-yl)methyl, or a salt, a hydrate, a solvate, or a stereoisomer thereof.

9. The compound of claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 5 is heterocyclyl or substituted heterocyclyl.

10. The compound of claim 9 , wherein R 5 is 4-(methoxymethyl)-1-methylpiperidin-4-yl; 3-(methoxymethyl)-1-methylazetidin-3-yl; 3-(methoxymethyl)oxetan-3-yl; 3-((dimethylamino)methyl)oxetan-3-yl; oxetan-3-yl; 4-methoxy-1-methylpyrrolidin-3-yl; 6-methoxyhexahydrofuro[3,2-b]furan-3-yl; or 6-(dimethylamino)hexahydrofuro[3,2-b]furan-3-yl; or a salt, a hydrate, a solvate, or a stereoisomer thereof.

11. The compound of claim 1 , wherein the compound is of formula (Ia):

wherein

R 3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl;

R 5 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl; and

R 6 and R 7 are each independently hydrogen, halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy or sulfonyl, wherein m and n are each independently an integer from 1 to 5;

or a salt, a hydrate, a solvate, or a stereoisomer thereof.

12. The compound of claim 11 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein R 3 is C 1 -C 6 alkyl, heteroaryl or substituted heteroaryl.

13. The compound of claim 11 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 6 is halogen.

14. The compound of claim 11 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 7 is halogen.

15. The compound of claim 1 , wherein the compound is of formula (Ib):

wherein

R 5 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl; and

R 6 and R 7 are each independently hydrogen, halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy or sulfonyl, wherein m and n are each independently an integer from 1 to 5;

or a salt, a hydrate, a solvate, or a stereoisomer thereof.

16. The compound of claim 15 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 6 is halogen.

17. The compound of claim 15 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 7 is halogen.

18. The compound of claim 1 , wherein the compound is of formula (Ic):

wherein

R 3 is furanyl or substituted furanyl;

R 5 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl,

substituted aryl, heteroaryl or substituted heteroaryl; and

R 6 and R 7 are each independently hydrogen, halogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy or sulfonyl, wherein m and n are each independently an integer from 1 to 5;

or a salt, a hydrate, a solvate, or a stereoisomer thereof.

19. The compound of claim 18 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 6 is halogen.

20. The compound of claim 18 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, wherein at least one R 7 is halogen.

21. A compound selected from the group consisting of:

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 1);

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 2);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 3);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 4);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 5);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 6);

4-butyl-1-(3-fluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 7);

4-butyl-1-(3-fluorophenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 8);

4-butyl-1-(2,5-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 9);

4-butyl-3-(3,4-difluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 10);

4-butyl-1-(3-chloro-4-fluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-5-methylhexyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 11);

4-butyl-1-(4-chlorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 12);

4-butyl-1-(4-chlorophenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 13);

4-butyl-1,3-bis(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 14);

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-p-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 15);

4-butyl-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-1-p-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 16);

4-butyl-1-(3-chlorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 17);

4-butyl-1-(4-fluoro-3-methoxyphenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 18);

4-butyl-1-(4-fluoro-3-methoxyphenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 19);

3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-phenyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 20);

3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-phenyl-4-(pyridin-4-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 21);

4-butyl-1-(2-chloro-4-fluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 22);

4-butyl-1-(4-chloro-2-fluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 23);

4-butyl-1-(2,4-difluorophenyl)-N-(3-(dimethylamino)propyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 24);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(4-methoxybutyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 25);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-N,5-dimethyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 26);

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 28);

4-butyl-1-(4-chloro-2-methylphenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 29);

4-butyl-1-(4-chloro-2-methylphenyl)-3-(4-fluorophenyl)-N-(3-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 30);

methyl 3-(4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)propanoate (Compound 31);

4-butyl-1-(2,4-difluorophenyl)-N-(2-ethoxyethyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 32);

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxypentyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 33);

4-butyl-3-(4-fluorophenyl)-N-(6-hydroxyhexyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 34);

4-butyl-3-(4-fluorophenyl)-N-(4-hydroxybutyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 35);

4-butyl-3-(4-fluorophenyl)-N-(4-hydroxybenzyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 36);

4-butyl-3-(4-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 37);

4-butyl-3-(4-fluorophenyl)-N-(4-hydroxyphenethyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 38);

4-butyl-N-(3-chlorobenzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 39);

4-butyl-N-(3,4-dichlorobenzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 40);

4-butyl-N-(3,5-dichlorobenzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 41);

4-butyl-3-(4-fluorophenyl)-5-methyl-1-phenyl-N—((S)-1-phenylethyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 42);

4-butyl-3-(4-fluorophenyl)-5-methyl-1-phenyl-N—((R)-1-phenylethyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 43);

4-butyl-3-(4-fluorophenyl)-N-(2-methoxybenzyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 44);

4-butyl-N-(2,3-dimethoxybenzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 45);

4-butyl-N-(2,4-dimethoxybenzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 46);

4-butyl-N-(3,4-dimethoxybenzyl)-3-(4-fluorophenyl)-N,5-dimethyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 47);

4-butyl-N-(4-(dimethylamino)benzyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 48);

4-butyl-N-(3-(dimethylamino)propyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 49);

4-butyl-N-(3-(dimethylamino)-2,2-dimethylpropyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 50);

4-butyl-N-(cyclohexylmethyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 51);

4-butyl-N-(3,5-dimethoxybenzyl)-3-(4-fluorophenyl)-N,5-dimethyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 52);

4-butyl-3-(4-chloro-2-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 53);

4-butyl-3-(4-chloro-2-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 54);

4-butyl-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-1-m-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 55);

4-butyl-3-(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 56);

4-butyl-3-(2,4-difluorophenyl)-N-(2-methoxyethyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 57);

4-butyl-3-(4-chlorophenyl)-N-(2-methoxyethyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 58);

4-butyl-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-1-p-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 59);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 60);

4-butyl-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-1-m-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 61);

3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(thiophen-2-yl)-1-p-tolyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 63);

4-butyl-1-(4-chloro-2-fluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 64);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-(3-morpholinopropyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 65);

4-butyl-3-(4-fluorophenyl)-N-(4-hydroxy-3-methoxybenzyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 66);

4-butyl-3-(4-fluorophenyl)-5-methyl-1-phenyl-N-(thiophen-2-ylmethyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 67);

4-butyl-3-(4-fluorophenyl)-5-methyl-1-phenyl-N-((tetrahydro-2H-pyran-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 68);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-(1-(4-(methylsulfonyl)phenyl)ethyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 69);

4-butyl-N-(2-fluoroethyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 70);

4-butyl-3-(4-fluorophenyl)-5-methyl-1-phenyl-N-(3-(piperidin-1-yl)propyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 71);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-neopentyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 72);

4-butyl-N-(cyclopropylmethyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 73);

4-butyl-N-(2-(dimethylamino)-2-methylpropyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 74);

4-butyl-N-(3-(dimethylamino)butyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 75);

4-butyl-N-(2-(dimethylamino)propyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 76);

4-butyl-N-(3-(dimethylamino)-2-methylpropyl)-3-(4-fluorophenyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 77);

N-benzyl-4-butyl-3-(4-fluorophenyl)-N-(2-hydroxyethyl)-5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 78);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-(2-(methylsulfonyl)ethyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 79);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-(4-(morpholinomethyl)benzyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 80);

methyl 2-(4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 81);

2-(4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)acetic acid (Compound 82);

4-butyl-N-(2-cyanoethyl)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 83);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-hydroxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 84);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4-(thiophen-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 85);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(thiophen-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 86);

4-butyl-1,3-bis(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 89);

4-butyl-1,3-bis(2,4-difluorophenyl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 90);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-4-(furan-2-yl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 91);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-4-(furan-2-yl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 92);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4-(1-methyl-1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 93);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(1-methyl-1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 94);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4-(1-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 95);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(1-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 96);

4-butyl-1-(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-3-(2,4,6-trifluorophenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 97);

methyl 2-(4-butyl-1-(2,4-difluorophenyl)-5-methyl-3-(2,4,6-trifluorophenyl)-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 98);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4-(5-methylthiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 99);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(5-methylthiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 100);

4-(5-chlorothiophen-2-yl)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 101);

4-(5-chlorothiophen-2-yl)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 102);

methyl 2-(1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 103);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-(2-hydroxy-2-methylpropylamino)-2-oxoethyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 104);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(1,1-dioxo-1-thiomorpholine-2-oxoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 105);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-morpholino-2-oxoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 106);

1-(2,4-difluorophenyl)-N-(2-(2-(dimethylamino)ethylamino)-2-oxoethyl)-3-(4-fluorophenyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 107);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-(oxetan-3-ylamino)-2-oxoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 108);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-(2-(methylsulfonyl)ethylamino)-2-oxoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 109);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-(3-hydroxy-3-methylcyclobutylamino)-2-oxoethyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 110);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-(methoxy(methyl)amino)-2-oxoethyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 111);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-(2-(2-hydroxyethylamino)-2-oxoethyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 112);

4-butyl-1-(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-3-(4-(methylsulfonyl)phenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 113);

4-butyl-1-(2,4-difluorophenyl)-N-(2-methoxyethyl)-5-methyl-3-(4-(methylsulfonyl)phenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 114);

1,3-bis(2,4-difluorophenyl)-4-(furan-2-yl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 115);

1,3-bis(2,4-difluorophenyl)-4-(furan-2-yl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 116);

1,3-bis(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4-(thiophen-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 117);

1,3-bis(2,4-difluorophenyl)-N-(2-methoxyethyl)-5-methyl-4-(thiophen-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 118);

methyl 2-(1,3-bis(2,4-difluorophenyl)-5-methyl-4-(thiophen-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 119);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 120);

methyl 2-(4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 121);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(3-morpholinopropyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 122);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-(methylamino)-2-oxoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 123);

1-(2,4-difluorophenyl)-N-(2,4-dihydroxybutyl)-3-(4-fluorophenyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 124);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 125);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-(2-morpholinoethyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 126);

1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 127);

2-hydroxyethyl 2-(1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-4-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 128);

1,3-bis(2,4-difluorophenyl)-4-(furan-3-yl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 129);

1,3-bis(2,4-difluorophenyl)-4-(furan-3-yl)-N-(2-methoxyethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 130);

methyl 2-(1,3-bis(2,4-difluorophenyl)-4-(furan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)acetate (Compound 131);

(2S)-methyl 2-(1,3-bis(2,4-difluorophenyl)-4-(furan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)propanoate (Compound 132);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 133);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 135);

5-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(5-hydroxy-4,4-dimethylpentyl)-4-methyl-4,5-dihydro-1H-pyrazole-4-carboxamide (Compound 136);

methyl 2-(5-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-4-carboxamido)acetate (Compound 137);

tert-butyl 2-((4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)methyl)morpholine-4-carboxylate (Compound 138);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-(((R)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 139);

(4S,5R)-4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-(((R)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 140);

(4R,5S)-4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-(((R)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 141);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-q(S)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 142);

(4S,5R)-4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-q(S)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 143);

(4R,5S)-4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-q(S)-4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 144);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((4-ethylmorpholin-2-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 145);

4-(5-chlorofuran-2-yl)-N-((4-cyclopropylmorpholin-2-yl)methyl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 146);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((4-isopropylmorpholin-2-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 147);

1,3-bis(2,4-difluorophenyl)-5-methyl-4-(5-methylfuran-2-yl)-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 148);

1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4-(5-(trifluoromethyl)furan-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 149);

1,3-bis(2,4-difluorophenyl)-5-methyl-4-(5-(methylcarbamoyl)furan-2-yl)-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 150);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(4-methoxy-1-methylpiperidin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 151);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(4-(methoxymethyl)-1-methylpiperidin-4-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 152);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((3-methoxy-1-methylazetidin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 153);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(3-(methoxymethyl)-1-methylazetidin-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 154);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((3-methoxyoxetan-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 155);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(3-(methoxymethyl)oxetan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 156);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((3-(dimethylamino)oxetan-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 157);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(3-((dimethylamino)methyl)oxetan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 158);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((4,6-dimethylmorpholin-2-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 159);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4(4,6,6-trimethylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 160);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((7-methyl-4-oxa-7-azaspiro[2.5]octan-5-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 161);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((8-methyl-2,5-dioxa-8-azaspiro[3.5]nonan-6-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 162);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((2,8-dimethyl-5-oxa-2,8-diazaspiro[3.5]nonan-6-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 163);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((4,5-dimethylmorpholin-2-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 164);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4,5,5-trimethylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 165);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4-methyl-7-oxa-4-azaspiro[2.5]octan-6-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 166);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((5-methyl-2,8-dioxa-5-azaspiro[3.5]nonan-7-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 167); 4 (5 chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((2,5-dimethyl-8-oxa-2,5-diazaspiro[3.5]nonan-7-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 168);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-((4,5,6-trimethylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 169);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-N-(oxetan-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 170);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(2-(2-(dimethylamino)ethoxy)ethyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 171);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(3-(dimethylamino)-2-methoxypropyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 172);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(4-methoxy-1-methylpyrrolidin-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 173);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((3S,6R)-6-methoxyhexahydrofuro[3,2-b]furan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 174);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-((3S,6S)-6-(dimethylamino)hexahydrofuro[3,2-b]furan-3-yl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 175);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(((8aS)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 176);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(((8aR)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 177);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(((9aS)-hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 178);

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-N-(((9aR)-hexahydro-1H-[1,4]oxazino[3,4-c][1,4]oxazin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 179);

4-(5-chlorofuran-2-yl)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 180);

4-butyl-1-(4-chloro-2-fluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 181);

4-butyl-1-(4-chloro-2-fluorophenyl)-3-(4-fluorophenyl)-N-((3-methoxy-1-methylazetidin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 182);

1-(4-chloro-2-fluorophenyl)-4-(5-chlorofuran-2-yl)-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 183);

4-(5-chlorofuran-2-yl)-3-(4-chlorophenyl)-1-(2,4-difluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 184);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 185);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-((3-methoxy-1-methylazetidin-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 186);

4-butyl-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-N-((3-methoxyoxetan-3-yl)methyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 187);

4-(5-chlorofuran-2-yl)-3-(4-fluorophenyl)-5-methyl-N-((4(4-methylmorpholin-2-yl)methyl)-1-(p-tolyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 188);

4-butyl-3-(4-fluorophenyl)-5-methyl-N-((4-methylmorpholin-2-yl)methyl)-1-(p-tolyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 189);

4-butyl-3-(4-fluorophenyl)-N-((3-methoxy-1-methylazetidin-3-yl)methyl)-5-methyl-1-(p-tolyl)-4,5-dihydro-1H-pyrazole-5-carboxamide (Compound 190); and

4-butyl-3-(4-fluorophenyl)-N-((3-methoxyoxetan-3-yl)methyl)-5-methyl-1-(p-tolyl)-4,5 dihydro-1H-pyrazole-5-carboxamide (Compound 191),

or a salt, a hydrate, a solvate, or a stereoisomer thereof.

22. A pharmaceutical composition comprising:

(i) the compound according to claim 1 , or a salt, a hydrate, a solvate, or a stereoisomer thereof, and

(ii) a pharmaceutically acceptable carrier.

23. The compound of claim 1 , wherein the compound is a compound selected from the group consisting of:

or a salt, a hydrate, or a solvate, or a stereoisomer thereof.

24. A compound selected from the group consisting of:

or a salt, a hydrate, or a solvate, or a stereoisomer thereof.