Granted Patent B2

US 11,243,217 · App. 16/307,366 · Granted Feb 8, 2022

Inventors: Paul McPherson (Encinitas, CA); James Patrick Kampf (San Diego, CA); John A. Kellum (Pittsburgh, PA)

Assignees: Astute Medical, Inc.; University of Pittsburgh—of the Commonwealth System of Higher Education

G01N33/74G01N33/493G01N33/68G01N2800/347

Abstract

Claims (8)

1. A method of treating frail kidney in a subject, the method comprising administering an angiotensin receptor blocker (ARB), administering an ACE inhibitor (ACE-I), administering an agent for interrupting a renin-angiotensin-aldosterone system (RAAS), performing remote ischemic preconditioning, performing surgery using an off-pump technique, or withdrawing delivery of compounds that are known to be damaging to the kidney, to a subject having a frail kidney risk score below a predetermined threshold value,

wherein the risk score is based on a concentration of IGFBP7 (insulin-like growth factor-binding protein 7) and a concentration of TIMP-2 (tissue inhibitor of metalloproteinase 2) in a urine sample obtained from the subject,

wherein the risk score is based on the formula ([TIMP-2]×[IGFBP7])/1000 and is at or below about 0.07, and wherein the [TIMP-2] and [IGFBP7] are in units of ng/ml.

2. The method of claim 1 , wherein the risk score is lower than a threshold value selected based on the results of a population study of healthy individuals,

wherein the threshold value is the risk score value for the lowest tenth percentile of risk scores in the population.

3. The method of claim 1 , wherein the subject is expected to undergo major vascular surgery, coronary artery bypass surgery, or cardiac surgery.

4. A method of claim 2 , wherein the threshold value is about 0.07.

5. The method of claim 4 , wherein the subject is expected to undergo major vascular surgery, coronary artery bypass surgery, or cardiac surgery.

Assignments (7)