IP Library Granted Patent US 11,458,093
Granted Patent B2
US 11,458,093 · App. 16/309,787 · Granted Oct 4, 2022

Nicotine particles

Inventor: Nicolo Volpe (Lausanne, CH)
Assignee: Philip Morris Products S.A.
A61K9/0075A61K9/1617A61K9/1623A61K9/1682A61K31/465
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Quick Facts
Patent No.
US 11,458,093
App. No.
16/309,787
Granted
Oct 4, 2022
Kind
B2
Abstract

A method includes combining nicotine with a liquid carrier to form a liquid mixture and spray drying the liquid mixture to form a first plurality of particles. The first pluralities of particles are then milled to form a second plurality of particles.

Claims (15)

1. A method, comprising:

combining nicotine salt, sugar, and leucine with a liquid carrier, wherein the liquid carrier is water, to form a liquid mixture consisting of the liquid carrier, the nicotine salt, the sugar, and the leucine; and

spray drying the liquid mixture to form a first plurality of particles; and

milling the first plurality of nicotine particles to form a second plurality of particles,

wherein the first plurality of nicotine particles comprises about 90% by volume of the particles having a particle size of about 4.5 micrometres or less, and about 50% by volume of the particles having a particle size of less than about 2.5 micrometres and about 10% by volume of the particles having a particle size of less than about 0.85 micrometres, and

wherein the second plurality of nicotine particles comprises about 90% by volume of the plurality of particles having a particle size of less than about 2.8 micrometres, and about 50% of the plurality of particles have a particle size of less than about 1.35 micrometres, and about 10% of the second plurality of particles having a particle size of less than about 0.65 micrometres.

2. The method according to claim 1 , wherein the milling step comprises fluid energy milling and the fluid energy milling decreases a mass median aerodynamic diameter of the first plurality of particles to a mass median aerodynamic diameter of the second plurality of particles by a ratio of about 1.2:1 to about 5:1.

3. The method according to claim 1 , wherein the nicotine salt comprises nicotine lactate, nicotine pyruvate, nicotine citrate, or nicotine aspartate.

4. The method according to claim 1 further comprising packaging the second plurality of particles in an inhalation delivery consumable element.

5. The method of claim 1 , wherein the spray drying comprises an inlet temperature of 140 degrees Celsius or less.

6. The method of claim 1 , wherein the spray drying comprises an outlet temperature of 30 degrees Celsius to 90 degrees Celsius.

7. The method of claim 1 , wherein the spray drying comprises an outlet temperature of 40 degrees Celsius to 85 degrees Celsius.

8. The method of claim 1 , wherein the second plurality of particles comprises from 1 wt % to 10 wt % nicotine.

9. The method of claim 1 , wherein the second plurality of particles comprises from 70 wt % to 90 wt % sugar.

10. The method of claim 1 , wherein the sugar comprises lactose, sucrose, raffinose, trehalose, fructose, dextrose, glucose, maltose, mannitol, or a combination thereof.

Assignments (1)
DECLARATION OF ASSIGNMENT Recorded Aug 26, 2022
From: VOLPE, NICOLO
To: PHILIP MORRIS PRODUCTS S.A.
Reel/Frame 061384/0783 →
Priority Claims (1)
EP 16177156 · Jun 30, 2016 · regional
Continuity (1)
Related Publication 20190117567A1 · Apr 25, 2019