Method and system for treating lesions

1. A method of treating a lesion comprising:

inserting a mechanical waveguide into a vessel of a body of a subject, a lesion being present in the vessel and the mechanical waveguide extending longitudinally between a proximal end and a distal end;

positioning the distal end of the mechanical waveguide adjacent to the lesion;

generating, using a pulse generator operatively connected to the proximal end of the mechanical waveguide, a high amplitude broadband mechanical pulse and propagating the high amplitude broadband mechanical pulse from the proximal end to the distal end of the mechanical waveguide; and

propagating at least a portion of the high amplitude broadband mechanical pulse from the distal end of the mechanical waveguide to the lesion, the at least a portion of the high amplitude broadband mechanical pulse propagating up to the lesion, thereby treating at least partially the lesion.

2. The method of claim 1 , further comprising imaging a portion of the body comprising the vessel having the lesion therein.

3. The method of claim 2 , wherein said inserting the mechanical waveguide comprises inserting the mechanical waveguide having a marker positioned at the distal end thereof.

4. The method of claim 1 , further comprising deflecting the at least a portion of the high amplitude broadband mechanical pulse before reaching the lesion.

5. The method of claim 4 , wherein said deflecting occurs at the distal end of the mechanical waveguide.

6. The method of claim 4 , wherein said deflecting occurs away from the distal end of the mechanical waveguide.

7. The method of claim 1 , wherein said generating comprises generating a plurality of broadband mechanical waves having a first amplitude and combining the plurality of broadband mechanical waves, thereby obtaining the high amplitude broadband mechanical pulse having a second amplitude greater than the first amplitude.

8. The method of claim 7 , wherein said combining the plurality of broadband mechanical waves comprises focusing the plurality of broadband mechanical waves on a focus zone.

9. The method of claim 7 , wherein said combining the plurality of broadband mechanical waves comprises propagating the plurality of broadband mechanical waves into a temporal concentrator.

10. The method of claim 7 , wherein said combining the plurality of broadband mechanical waves comprises propagating the plurality of broadband mechanical waves in a taper.

11. The method of claim 7 , wherein said combining the plurality of broadband mechanical waves comprises propagating the plurality of broadband mechanical waves in a reverberating cavity.

12. The method of claim 7 , wherein said combining the plurality of broadband mechanical waves comprises propagating the plurality of broadband mechanical waves in a dispersive medium.

13. The method of claim 1 , wherein the high amplitude broadband mechanical pulse has a center frequency fc comprised between about 20 kHz and about 10 MHz and a duration of about 1/fc.

14. The method of claim 1 , wherein an amplitude of the high amplitude broadband mechanical pulse when reaching the distal end of the mechanical waveguide is comprised between about 1 MPa and about 1000 MPa.

15. The method of claim 1 , wherein said positioning the distal end of the mechanical waveguide adjacent to the lesion comprises positioning the distal end of the mechanical waveguide to be in contact with the lesion in the blood vessel.

16. A system for treating a lesion, comprising:

a pulse generator for generating at least one high amplitude broadband mechanical pulse; and

a mechanical waveguide extending between a proximal end and a distal end, the proximal end being coupled to the pulse generator for receiving the at least one high amplitude broadband mechanical pulse therefrom, the mechanical waveguide for propagating the at least one high amplitude broadband mechanical pulse from the proximal end to the distal end and transmitting the at least one high amplitude broadband mechanical pulse at the distal end, the distal end being adapted to be introduced into a vessel of a subject comprising the lesion.

17. The system of claim 16 , wherein the pulse generator comprises:

a plurality of broadband sources each for emitting a respective mechanical wave having a first amplitude; and

a wave concentrator for combining the respective mechanical waves in order to obtain the at least one high amplitude broadband mechanical pulse having a second amplitude greater than the first amplitude.

18. The system of claim 17 , wherein the wave concentrator is a spatial concentrator.

19. The system of claim 17 , wherein the wave concentrator is a temporal concentrator.

20. The system of claim 17 , wherein the wave concentrator is adapted to focus the respective mechanical waves on a focus zone adjacent to the proximal end of the mechanical waveguide.

21. The system of claim 20 , wherein the wave concentrator comprises a parabolic reflecting surface for reflecting at least some of the respective mechanical waves generated by the plurality of broadband sources towards the focus zone.

22. The system of claim 17 , wherein the wave concentrator is a taper.

23. The system of claim 17 , wherein the wave concentrator comprises a spatial concentration stage and a temporal concentration stage.

24. The system of claim 16 , wherein the at least one high amplitude broadband mechanical pulse each have a center frequency fc comprised between about 20 kHz and about 10 MHz and a duration of about 1/fc.

25. The system of claim 16 , wherein an amplitude of the at least one high amplitude broadband mechanical pulse when reaching the distal end of the mechanical waveguide is comprised between about 1 MPa and about 1000 MPa.

26. The system of claim 16 , wherein the mechanical waveguide is flexible.

27. The system of claim 16 , further comprising a deflector for deflecting and orienting the at least one high amplitude broadband mechanical pulse.

28. The system of claim 27 , wherein the deflector is integral with the mechanical waveguide.

29. The system of claim 28 , wherein the deflector comprises a beveled face.

30. The system of claim 27 , wherein the deflector projects from the distal end of the mechanical waveguide.

31. The system of claim 30 , wherein the deflector has a truncated conical shape.

32. The system of claim 27 , wherein the deflector is independent from the mechanical waveguide.

33. The system of claim 16 , wherein the distal end of the waveguide is positionable to be in contact with the lesion in the blood vessel.