Antiparasitic Compounds

1 . A compound of Formula (I):

wherein:

R 1 is optionally substituted aryl or optionally substituted heteroaryl;

R 2 is alkyl or haloalkyl;

each of A, B, and D individually is CR 5 or N;

each R 5 individually is hydrogen, alkyl, halogen, haloalkyl, or aryl;

X is L 1 -L 2 -L 3 ;

each of L 1 , L 2 , and L 3 individually is bond, C(O), (CH 2 ) n , SO 2 , O, or NH;

n is 1 to 6;

R 3 is hydrogen, alkyl, or ═O; and

R 4 is hydrogen, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;

or a pesticidally, veterinarily, or pharmaceutically acceptable salt thereof.

2 . The compound according to claim 1 , wherein:

R 1 is aryl optionally substituted with 1-3 substituents selected from halogen, haloalkyl, or alkyl; or

R 1 is heteroaryl optionally substituted with 1-3 substituents selected from halogen, haloalkyl, or alkyl;

3 . The compound according to claim 1 , wherein:

R 2 is CF 3 or CH 3 .

4 . The compound according to claim 1 , wherein:

i) each of A, B, and D is CH;

ii) A is CH, B is N, and D is CH; or

iii) A is CH, B is CH, and D is N;

5 . The compound according to claim 1 , wherein:

i) L 1 is C(O), L 2 is (CH 2 ) n and n is 1, and L 3 is bond;

ii) L 1 is C(O), L 2 is (CH 2 ) n and n is 1, and L 3 is SO 2 ;

iii) L 1 is C(O), L 2 is bond, and L 3 is bond;

iv) L 1 is C(O), L 2 is NH, and L 3 is (CH 2 ) n and n is 1;

v) L 1 is SO 2 , L 2 is (CH 2 ) n and n is 1, and L 3 is bond

6 . The compound according to claim 1 , wherein:

R 3 is hydrogen or ═O.

7 . The compound according to claim 1 , wherein:

R 4 is C 1-6 alkyl or C 1-6 haloalkyl,

8 . (canceled)

9 . A combination comprising:

a compound of claim 1 ; and

one or more other pesticidally, veterinarily, or pharmaceutically active substances.

10 . A composition comprising a compound of claim 1 and an acceptable carrier.

11 . A method for controlling parasites at a locus which comprises applying to the locus an effective amount of a composition of claim 10 .

12 . A method of treating or preventing parasitic infection or infestation in a subject, the method comprising administering to the subject an effective amount of a compound of claim 1 .

13 . (canceled)

14 . The method of claim 12 , wherein the parasite is a flea or tick.

15 . The method of claim 12 , wherein the parasite is Ctenocephalides felis, R. sanguineus, D. variablis or I. scapularis.

16 . The method of claim 12 , wherein the parasite is a helminth.

17 . The method of claim 12 , wherein the parasite is Dirofilaria immitis.

18 . (canceled)