Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by

1. A method for treating disorders associated to the inflammation induced by P. acnes comprising administering to a subject in need thereof an effective amount of a compound of following general formula (II):

or a pharmaceutically acceptable salt and/or solvate thereof, wherein:

X′, Y′ and Z′ are, independently of one another, CH, CH 2 , NH or N;

W′ is CHR′3, S═O or S;

R′ 1 and R′ 2 are, independently of one another, hydrogen atom, halo, —CN, —NO 2 , —CF 3 , —OR′ 7 , —NR′ 8 R′ 9 , or a (C 1 -C 6 )alkyl group;

R′ 3 is H, —CN, OR′ 10 , or a (C 1 -C 6 )alkyl group;

R′ 4 and R′ 5 , are, independently of one another, hydrogen atom or a group selected from halo, —NO 2 , —CN, —OR′ 11 , —NR′ 12 R′ 13 , —C(O)OR′ 14 , —S(O) 2 R′ 15 , or a (C 1 -C 6 )alkyl group optionally substituted with one or several groups selected from halo or —OR′ 16 ;

R′ 7 to R′ 16 are, independently of one another, hydrogen atom or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, CF 3 or —OR′ 17 ;

R′ 17 is hydrogen atom, halo or a (C 1 -C 6 )alkyl group.

2. The method of claim 1 , wherein said compound is a compound of the following general formula (IIa):

or a pharmaceutically acceptable salt and/or solvate thereof, wherein:

X′, Y′ and Z′ are, independently of one another, CH, CH 2 , NH, or N;

R′ 1 and R′ 2 are, independently of one another, hydrogen atom, halo, —CN, —NO 2 , —CF 3 , —OR′ 7 , —NR′ 8 R′ 9 , or a (C 1 -C 6 )alkyl group;

R′ 3 is H, —CN, OR′ 10 , or a (C 1 -C 6 )alkyl group;

R′ 4 and R′ 5 , are, independently of one another, hydrogen atom or a group selected from halo, —NO 2 , —CN, —OR′ 11 , —NR′ 12 R′ 13 , —C(O)OR′ 14 , —S(O) 2 R′ 15 , or a (C 1 -C 6 )alkyl group optionally substituted with one or several groups selected from halo or —OR′ 16 ;

R′ 7 to R′ 16 are, independently of one another, hydrogen atom, or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, CF 3 or —OR′ 17 ;

R′ 17 is hydrogen atom, halo or a (C 1 -C 6 )alkyl group.

3. The method of claim 1 , wherein X′, Y′, and Z′ are each a nitrogen atom.

4. The method of claim 1 , wherein R′ 3 is —CN, or OH.

5. The method of claim 1 , wherein and R′ 1 and R′ 2 are, independently of one another, hydrogen atom, halo, —CF 3 , —OH, or a (C 1 -C 6 )alkyl group.

6. The method of claim 1 , wherein R′ 5 is an hydrogen atom and R′ 4 is selected from the group consisting of hydrogen atom, halo, —CF 3 , —OH, and a (C 1 -C 6 )alkyl group.

7. The method of claim 1 , wherein said compound is a compound of the following general formula (IIb):

or a pharmaceutically acceptable salt and/or solvate thereof.

8. The method of claim 1 , wherein said compound is a compound of the following formula (IId):

or a pharmaceutically acceptable salt and/or solvate thereof.

9. The method of claim 1 , wherein said disorders associated to the inflammation induced by P. acnes are acne, psoriasis, chronic urticaria, urticaria pigmentosa, cutaneous autoinflammatory diseases, hidradenitis, or atopic dermatis.

10. A method for treating disorders associated to the inflammation induced by P. acnes comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising at least one compound of claim 1 and at least one pharmaceutically acceptable excipient.

11. The method of claim 10 , wherein said composition further comprises another active principle selected from the group consisting of a topical antibiotic, topical anti-inflammatory, topical anti-seborrheic zinc derivative, cyclin, and isotretinoin.

12. The method of claim 10 , wherein said composition further comprises another active principle selected from the group consisting of erythromycine, dalacine, benzoyl peroxyde derivatives, isotretinoin, tretinoin, adapalene, zinc gluconate, cyclins, and isotretinoin.