Anti-canine platelet derived growth factor receptor alpha antibody
The present disclosure relates to anti-canine platelet derived growth factor receptor alpha antibodies binding to canine platelet derived growth factor receptor alpha.
1. A monoclonal antibody comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3 and the HCVR comprises CDRs HCDR1, HCDR2, and HCDR3, wherein the amino acid sequence of LCDR1 is given by SEQ ID NO:16, the amino acid sequence of LCDR2 is given by SEQ ID NO: 18, the amino acid sequence of LCDR3 is given by SEQ ID NO: 20, the amino acid sequence of HCDR1 is given by SEQ ID NO: 6, the amino acid sequence of HCDR2 is given by SEQ ID NO: 8, and the amino acid sequence of HCDR3 is given by SEQ ID NO: 10; and wherein the monoclonal antibody binds canine platelet derived growth factor receptor alpha (cPDGFRA).
2. The monoclonal antibody of claim 1 , comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the amino acid sequence of the LCVR is given by SEQ ID NO: 14 and the amino acid sequence of the HCVR is given by SEQ ID NO: 4.
3. The monoclonal antibody of claim 1 , comprising a light chain (LC) and a heavy chain (HC), wherein the amino acid sequence of the LC is given by SEQ ID NO: 12 and the amino acid sequence of the HC is given by SEQ ID NO: 1.
4. A method of treating osteosarcoma in a canine, comprising administration of the monoclonal antibody of claim 1 to a canine in need thereof.
5. A method of treating osteosarcoma in a canine, comprising administration of the monoclonal antibody of claim 2 to a canine in need thereof.
6. A method of treating osteosarcoma in a canine, comprising administration of the monoclonal antibody of claim 3 to a canine in need thereof.