Compositions and the use thereof for treating or preventing rosacea

1. A composition comprising:

(a) ivermectin, present at a concentration of 0.01 to 5% by weight, relative to the total weight of the composition;

(b) diclofenac or a pharmaceutically acceptable salt thereof, present at a concentration of 1% to 3% by weight, relative to the total weight of the composition; and

(c) a pharmaceutically acceptable carrier,

wherein the composition is formulated for topical application.

2. The composition according to claim 1 , wherein the composition is in the form of a salve, an emulsion, a cream, a milk, an ointment, an impregnated pad, a syndet, a solution, a gel, a spray an aerosol, a foam, a suspension, a lotion or a stick.

3. The composition according to claim 2 , wherein the composition is in the form of an emulsion.

4. A method of treating or preventing rosacea in a subject in need thereof, the method comprising topically administering the composition of claim 1 to the subject.

5. The method according to claim 4 , wherein rosacea is selected in the group consisting of type I erythematous rosacea, type II papulopustular rosacea and ocular rosacea.

6. The method according to claim 5 , wherein rosacea is type II papulopustular rosacea.

7. The composition according to claim 1 , wherein the ivermectin is present at a concentration of 0.75%, 1%, 1.5%, or 2% by weight relative to the total weight of the composition.

8. The composition of claim 1 , wherein the ivermectin is present at a concentration of 1% relative to the total weight of the composition.

9. The composition of claim 1 , wherein the ivermectin and the diclofenac or pharmaceutically acceptable salt thereof are the sole active ingredients in the composition.