Acyl benzo[d]thiazol-2-amine and their methods of use
Disclosed are acyl benzo[d]thiazol-2-amines having a structure according to formula (I): including enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof. The compounds may be useful for the treatment of various diseases including, for example, neurological disorders such as amyotrophic lateral sclerosis, bipolar disorder, treatment resistant and major depression, general anxiety disorder, and cancers such as melanoma, breast cancer, brain cancer, and prostate cancer.
1. A compound having a structure according to formula (IX):
including pharmaceutically acceptable salts thereof, wherein:
R 1 , R 2 and R 3 are each independently hydrogen or halogen;
R 4 is hydrogen;
R 14a and R 14b are hydrogen;
R 15 is C 1 -C 6 alkyl;
R 17a and R 17b are hydrogen;
R 19a is C 1 -C 6 alkyl; and
R 19b is hydrogen.
2. The compound according to claim 1 selected from:
3. A composition comprising an effective amount of at least one compound according to claim 1 and at least one excipient.