Anti-OX40 binding proteins
View Patent ↗The present disclosure provides anti-OX40 antibodies, and antigen-binding portions thereof. In certain embodiments, the antibodies or fragments thereof, are used for the treatment of cancer.
1. An isolated anti-OX40 antibody, or an antigen-binding fragment thereof, wherein the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO: 24; and comprises a light chain variable domain comprising the amino acid sequence SEQ ID NO: 25.
2. The anti-OX40 antibody, or antigen-binding fragment thereof, of claim 1 , wherein the antibody is a human antibody.
3. The anti-OX40 antibody of claim 1 , which is an IgG.
4. The anti-OX40 antibody of claim 1 , wherein the antibody is an IgG1, IgG2, IgG3 or an IgG4 isotype.
5. The anti-OX40 antibody, or antigen-binding fragment thereof, of claim 1 , wherein the antigen-binding fragment is a Fab fragment or an scFv.
6. A pharmaceutical composition comprising the anti-OX40 antibody, or antibody fragment of claim 1 , and a pharmaceutically acceptable carrier.
7. An isolated anti-OX40 antibody, comprising:
a heavy chain and a light chain, wherein
(i) the heavy chain comprises: a heavy chain complementarity determining region 1 (CDR1) having the amino acid sequence of SEQ ID NO:118, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO:119, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO:120; and
(ii) the light chain comprises: a light chain CDR1 having the amino acid sequence of SEQ ID NO:121, a light chain CDR2 having the amino acid sequence of SEQ ID NO:122, and a light chain CDR3 having the amino acid sequence of SEQ ID NO:123.
8. The isolated anti-OX40 antibody of claim 7 , wherein the antibody is a human antibody.