Collagen/ORC dressing encapsulated within a bioresorbable envelope
Wound dressing compositions comprising of a bioresorbable sponge encapsulated within a polysaccharide envelope. The bioresorbable sponge is preferably comprised of collagen and oxidised regenerated cellulose. The outer polysaccharide envelope is preferably comprised of chitosan. The outer polysaccharide envelope functions to modulate the rate at which the bioresorbable sponge breaks down within a wound.
1. A wound dressing comprising
a bioresorbable sponge having a wound-facing surface and an opposite bottom surface, the bioresorbable sponge comprising oxidized regenerated cellulose (ORC) and collagen; and
a bioresorbable top sheet covering the wound-facing surface of the bioresorbable sponge, the top sheet comprising a polysaccharide polymer, the top sheet further comprising a perforation density of about 4/cm 2 , and the perforations have an average diameter of from about 0.02 cm to about 0.4 cm.
2. The wound dressing according to claim 1 , wherein the polysaccharide polymer is selected from the group consisting of alginates, chitosan, chitin, guar gums, starch derivatives, cellulose derivatives, glycosaminoglycans, chondroitin sulfate, heparin sulfate, and a mixture of any two or more thereof.
3. The wound dressing according to claim 1 , wherein an aqueous solution used to generate the top sheet has a solids content of from about 1% wt./vol. to about 5% wt./vol.
4. The wound dressing according to claim 1 , further comprising a bottom sheet.
5. The wound dressing according to claim 4 , wherein the bottom sheet comprises a resorbable polysaccharide.
6. The wound dressing according to claim 4 , wherein the top sheet and the bottom sheet are bonded so as to substantially encapsulate the bioresorbable sponge.
7. The wound dressing according to claim 1 , wherein the bioresorbable sponge further comprises a structural protein.
8. The wound dressing according to claim 7 , wherein the structural protein is selected from the group consisting of fibronectin, gelatin, fibrin, laminin, elastin, and a mixture of any two or more thereof.
9. The wound dressing according to claim 7 , wherein the bioresorbable sponge comprises at least 75% of a mixture of the ORC and the structural protein by weight.
10. The wound dressing according to claim 1 , wherein the bioresorbable sponge comprises a mixture of ORC and collagen, wherein the mixture comprises from about 50% to about 60% collagen by weight.
11. The wound dressing according to claim 1 , wherein the bioresorbable sponge is substantially planar, having a width of from about 3 cm to about 30 cm, and a length of from about 3 cm to about 30 cm.
12. The wound dressing according to claim 1 , further comprising an antimicrobial agent selected from the group consisting of tetracyclines, beta-lactams, macrolides, aminoglycosides, fluoroquinolones, silver, silver salts, and a mixture of any two or more thereof.