Treatment of B cell cancers using a combination comprising Btk inhibitors
Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. Also, disclosed a pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a targeted therapy agent and the use thereof.
1. A method for the delay of progression or treatment of a B cell cancer in a subject, comprising administering to the subject in need thereof (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, at a dose of 320 mg once a day (QD) or 160 mg twice a day (BID) in 28-day cycles, in combination with obinutuzumab administered by three loading doses of 1000 mg weekly followed by 1000 mg on day one of cycles 2-6, wherein the subject is a human.
2. The method of claim 1 , wherein the delay of progression or treatment of a B cell cancer in a subject is delay of progression of B cell cancer growth or inhibiting B cell cancer growth in the subject.
3. The method of claim 1 , wherein the B-cell cancer is a relapsed or refractory B-cell cancer.
4. The method of claim 3 , wherein the relapsed or refractory B-cell cancer is diffuse large B-cell lymphoma (DLBCL), activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL), germinal center B-cell diffuse large B-cell lymphoma (GCB-DLBCL) or non-germinal center B-cell diffuse large B-cell lymphoma (non-GCB DLCBCL).
5. The method of claim 1 , wherein the B-cell cancer is a metastasized B-cell cancer.
6. The method of claim 5 , wherein the metastasized B-cell cancer is diffuse large B-cell lymphoma (DLBCL), activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL), germinal center B-cell diffuse large B-cell lymphoma (GCB-DLBCL) or non-germinal center B-cell diffuse large B-cell lymphoma (non-GCB DLCBCL).
7. The method of claim 1 , wherein the B-cell cancer is chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), non-CLL/SLL lymphoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), Waldenström macroglobulinemia (WM), Hairy cell leukemia (HCL), Burkitt's-like leukemia (BL), B cell prolymphocytic leukemia (B-PLL), diffuse large B cell lymphoma (DLBCL), primary central nervous system lymphoma (PCNSL), secondary central nervous system lymphoma (SCNSL) of breast or testicular origin, multiple myeloma, or a combination of two or more thereof.
8. The method of claim 7 , wherein the DLBCL is activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL), germinal center B-cell diffuse large B-cell lymphoma (GCB-DLBCL), non-germinal center B-cell diffuse large B-cell lymphoma (Non-GCB DLBCL), or diffuse large B-cell lymphoma (DLBCL) with undetermined subtype.
9. The method of claim 7 , wherein the B-cell cancer is follicular lymphoma (FL).
10. The method of claim 9 , wherein the FL is relapsed or refractory.
11. The method of claim 9 , wherein the obinutuzumab is administered at a dose of 1,000 mg intravenously on days 1, 8, and 15 of cycle 1, followed by 1,000 mg intravenously on day 1 of each cycle of cycles 2 to 6; and each cycle is 28 days.
12. The method of claim 11 , wherein the FL is relapsed or refractory.
13. The method of claim 9 , wherein the (S)-7-(1-acryloylpiperidin-4-yl)-2-4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, is administered orally, and the obinutuzumab is administered intravenously.
14. The method of claim 13 , wherein the (S)-7-(1-acryloylpiperidin-4-yl)-2-4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, is administered at a dose of 160 mg twice a day (BID).
15. The method of claim 14 , wherein the FL is relapsed or refractory.
16. The method of claim 13 , wherein the (S)-7-(1-acryloylpiperidin-4-yl)-2-4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, is administered at a dose of 320 mg once a day (QD).
17. The method of claim 16 , wherein the FL is relapsed or refractory.
18. The method of claim 1 , wherein the (S)-7-(1-acryloylpiperidin-4-yl)-2-4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, is administered orally, and the obinutuzumab is administered intravenously.
19. The method of claim 11 , wherein the (S)-7-(1-acryloylpiperidin-4-yl)-2-4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, is administered orally.