Methods of prognosis and treatment
A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.
1. A method for triaging subjects comprising measuring the TRAIL protein level in a blood sample of a subject showing symptoms of an infectious disease, wherein the subject has a normal troponin level, and wherein when the TRAIL level is below 30 pg/ml, the subject is admitted to a hospital.
2. The method of claim 1 further comprising managing the subject with a management selected from the group consisting of mechanical ventilation, invasive monitoring, last-resort drug, sedation, intensive care admission and surgical intervention.
3. The method of claim 1 , wherein said blood sample is a fraction of whole blood.
4. The method of claim 3 , wherein said fraction is serum or plasma.
5. The method of claim 1 , wherein said blood sample comprises cells selected from the group consisting of lymphocytes, monocytes and granulocytes.
6. The method of claim 1 , wherein said measuring is determined electrophoretically or immunochemically.
7. The method of claim 6 , wherein said immunochemical determination is measured by lateral flow immunoassay, flow cytometry, radioimmunoassay, immunofluorescence or by an enzyme-linked immunosorbent assay.
8. The method of claim 1 , wherein the subject has an infectious disease.
9. The method of claim 1 , wherein the symptoms comprise fever.
10. The method of claim 1 , wherein the triaging further comprises measuring the level of at least one additional determinant selected from the group consisting of IP10, CRP, PCT, and IL-6.
11. The method of claim 1 , wherein when the TRAIL level is below 25 pg/ml, the subject is admitted to a hospital.