IP Library › Granted Patent US 12,514,792
Granted Patent B2
US 12,514,792 · App. 16/342,824 · Granted Jan 6, 2026

Methods and kits for removing calculus using a metal ion and bicarbonate

Inventors: Petra L. Kohler Riedi (Minneapolis, MN); Evan Koon Lun Yuuji Hajime (Woodbury, MN); Steven P. Swanson (Blaine, MN); Chuntao Cao (Woodbury, MN); Ingo R. Haeberlein (Weilheim, DE); Tao Gong (Woodbury, MN)
Assignee: Solventum Intellectual Properties Company
A61K6/79A61K8/19A61K8/20A61K33/06A61K33/10A61K33/14A61Q11/00A61K2800/88
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Quick Facts
Patent No.
US 12,514,792
App. No.
16/342,824
Granted
Jan 6, 2026
Kind
B2
Abstract

Methods and kits for removing calculus from a tooth, wherein the method can include applying a component A to the tooth, wherein component A comprises: a metal ion selected from the group of lithium ion, magnesium ion, calcium ion, a precursor thereto, and a combination thereof; and an aprotic base having a pKb in water of greater than 15.4, or a precursor thereto; applying a component B to the tooth, wherein component B comprises a bicarbonate ion or a precursor thereto; wherein components A and B are applied simultaneously or sequentially to the tooth, thereby generating a gas to soften and/or loosen at least part of the calculus on the tooth; and removing at least a part of the calculus from the tooth.

Claims (28)

1 . A method of removing calculus from a tooth, the method comprising:

applying a component A to the tooth,

component A is selected from calcium chloride and magnesium chloride, wherein component A is applied as an aqueous solution at a concentration of 3M or a saturated solution;

applying a component B to the tooth,

component B is a source of bicarbonate ion,

wherein component B is applied as an aqueous solution at a concentration of 1 M,

wherein component A and component B are applied simultaneously or sequentially to the tooth, and

wherein component A and component B generate gas when combined to soften and/or loosen at least part of the calculus on the tooth; and

removing at least a part of the calculus from the tooth.

2 . The method of claim 1 , wherein component A is applied before or after component B is applied.

3 . The method of claim 2 , wherein component A is applied for a period of less than 1 hour before applying component B.

4 . The method of claim 2 , wherein component B is applied for a period of less than 1 hour before applying component A.

5 . The method of claim 1 , wherein component A is a saturated aqueous solution.

6 . The method of claim 1 , wherein component A is an aqueous solution at a concentration of 3 M.

7 . The method of claim 1 , wherein the source of bicarbonate ion comprises a carbonate and an acid.

8 . The method of claim 1 , wherein component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

9 . A kit of parts for use in a method of removing calculus from a tooth according to claim 1 , the kit comprising:

a component A selected from calcium chloride and magnesium chloride, component A provided as an aqueous solution at a concentration of 3M or a saturated solution;

a component B is a source of bicarbonate ion, component B provided as an aqueous solution at a concentration of 1M; and

a set of instructions directing a user to:

apply component A and component B to the tooth simultaneously or sequentially, and

remove at least a part of the calculus from the tooth.

10 . The method of claim 1 component A is magnesium chloride and component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

11 . The method of claim 10 , wherein component A is an aqueous solution at a concentration of 3M.

12 . The method of claim 10 , wherein component A is a saturated aqueous solution.

13 . The method of claim 1 , component A is calcium chloride and component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

14 . The method of claim 13 , wherein component A is an aqueous solution at a concentration of 3M.

15 . The method of claim 13 , wherein component A is a saturated aqueous solution.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2024
From: 3M INNOVATIVE PROPERTIES COMPANY
To: SOLVENTUM INTELLECTUAL PROPERTIES COMPANY
Reel/Frame 066431/0915 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2019
From: KOHLER RIEDI, PETRA L.; HAJIME, EVAN KOON LUN YUJJI; SWANSON, STEVEN P.; CAO, CHUNTAO; HAEBERLEIN, INGO R.; GONG, TAO
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 050434/0707 →
Continuity (2)
Provisional Application 62410711 · Oct 20, 2016
Related Publication 20190231649A1 · Aug 1, 2019
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