THERAPY OF POST-OPERATIVE EMESIS WITH AMISULPRIDE
Amisulpride is useful in the therapy (particularly the prevention) of postoperative emesis in a patient, particularly wherein the patient is undergoing a surgical procedure where postoperative emesis would be potentially dangerous to the patient.
1 . Amisulpride for use in the therapy of postoperative emesis in a patient.
2 . Amisulpride, for use according to claim 1 , wherein the patient is undergoing a surgical procedure where postoperative emesis would be potentially dangerous to the patient.
3 . Amisulpride, for use according to claim 1 or claim 2 , in the prevention of post-operative emesis in the patient.
4 . Amisulpride, for use according to any preceding claim, wherein the post-operative emesis would place the patient at risk of aspiration into the lungs, suture dehiscence, oesophageal rupture, subcutaneous emphysema, bilateral pneumothoraxes venous hypertension, increased intracranial pressure, or hematomas such as those beneath surgical flaps, vascular anastomoses, and aneurysm clips.
5 . Amisulpride, for use according to any preceding claim, wherein the surgical procedure is selected from surgery of the mouth cavity, surgery of the ear, nose or throat (ENT), surgery of the head or face, surgery of the gastrointestinal (GI) tract, lung surgery, abdominal surgery and bowel surgery.
6 . Amisulpride, for use according to claim 5 , wherein the surgery of the mouth cavity is wired jaw surgery or dental surgery.
7 . Amisulpride, for use according to claim 5 , wherein the ENT surgery is a tonsillectomy or thyroidectomy.
8 . Amisulpride, for use according to claim 5 , wherein the surgery of the head or face is a craniotomy, hemorrhagic stroke surgery, ischemic stroke surgery, rhinoplasty, a cosmetic procedure of the face or eye surgery.
9 . Amisulpride, for use according to claim 5 , wherein the GI tract surgery is paraesophageal surgery, anti-reflux surgery, bariatric surgery, gastrectomy, gastric bypass surgery or gastric sleeve surgery.
10 . Amisulpride, for use according to claim 5 , wherein the lung surgery is a surgical lung biopsy, lobectomy or wedge resection.
11 . Amisulpride, for use according to claim 5 , wherein the abdominal surgery is a surgical hernia repair, a total abdominal hysterectomy, abdominoplasty, laparotomy, any surgery involving a large abdominal incision, or an open abdominal aortic aneurysm repair.
12 . Amisulpride, for use according to any preceding claim, wherein the amisulpride is administered in combination with another anti-emetic, either separately, sequentially or simultaneously.
13 . Amisulpride, for use according to claim 12 , wherein the other anti-emetic is a 5HT 3 antagonist, an NK 1 antagonist or a steroid.
14 . Amisulpride, for use according to claim 12 or claim 13 , wherein the another anti-emetic is dexamethasone, ondansetron, granisetron, palonosetron, aprepitant, netupitant or rolapitant.
15 . Amisulpride, for use according to any preceding claim, wherein the patient has at least 3 risk factors for post-operative emesis, wherein the risk factors are selected from a past history of postoperative nausea and vomiting and/or motion sickness; habitual non-smoking status; being a female; and expected use of post-operative opioid analgesia.
16 . Amisulpride, for use according to any preceding claim, wherein the amisulpride is substantially in the form of a racemate.
17 . Amisulpride, for use according to any one of claims 1 to 15 , wherein the amisulpride is in the form of (S-)-amisulpride, which is substantially free of the (R+)-enantiomer.
18 . Amisulpride, for use according to any preceding claim, wherein the amisulpride is administered via the intravenous route.
19 . Amisulpride, for use according to claim 18 , wherein the amisulpride is administered by infusion over about 1 to 2 minutes.
20 . Amisulpride, for use according to any preceding claim, wherein the amisulpride is administered in a single dose.
21 . Amisulpride, for use according to any preceding claim, wherein the amisulpride is administered at the time of induction of anaesthesia.
22 . Amisulpride, for use according to any preceding claim, wherein the dose of amisulpride is 1 to 40 mg.
23 . Amisulpride, for use according to any preceding claim, wherein the dose of amisulpride is 1 to 20 mg.
24 . Amisulpride, for use according to any preceding claim, wherein the dose of amisulpride is 5 to 10 mg.
25 . Amisulpride, for use according to any preceding claim, wherein the dose of amisulpride is 5 mg.
26 . A method for treating or preventing postoperative emesis in a patient, wherein the patient is undergoing a surgical procedure, comprising administering an effective amount of amisulpride to the patient.
27 . A method according to claim 26 , additionally comprising selecting a patient for the treatment or prevention, from a group of patients undergoing a surgical procedure where post-operative emesis would be potentially dangerous to the patient.
28 . A method according to claim 26 or claim 27 , additionally comprising selecting a patient for the treatment or prevention, from a group of patients having at least 3 risk factors for post-operative emesis, wherein the risk factors are selected from a past history of postoperative nausea and vomiting and/or motion sickness; habitual non-smoking status; being a female; and expected use of post-operative opioid analgesia.
29 . A method according any of claims 25 to 28 , having any one or more of the additional features of claims 1 to 25 .