Rubber-based soft gel skin adhesives
Adhesives comprising rubber, tackifier, oil, and optionally absorbent and active ingredient are described. The adhesives are suitable for medical applications as they are repositionable on skin. Also described are medical articles using the adhesives.
1. A rubber-based skin adhesive consisting of:
from about 7% to about 33% of at least one rubber component selected from the group consisting of a linear or radial A-B-A block copolymer, linear or radial A-B block copolymer, branched block copolymer, olefinic block copolymer and combinations thereof;
from about 15% 45% of at least one tackifier selected from the group consisting of a hydrogenated pentaerythritol rosin ester, a hydrogenated hydrocarbon resin, a styrenated terpene resin, and combinations thereof;
from about 15% about 60% of at least one mineral oil; and
from about 30% to about 40% of at least one absorbent;
at least one additive selected from the group consisting of a natural clay, a synthetic clay, a micro fibers, nano fibers, fibrils of fibers, an antioxidant, a stabilizer, and combinations thereof;
optionally, at least one active ingredient;
wherein the adhesive exhibits a soft, gel-like consistency and is repositionable on skin; and
wherein the ratio of the amount of the tackifier to the amount of the rubber component ranges from 1:1 to 2.4:1; and
wherein the ratio of the amount of the oil to the amount of the rubber component ranges from 1.3:1 to 2.6:1.
2. The adhesive of claim 1 wherein at least one absorbent comprises carboxymethyl cellulose.
3. The adhesive of claim 1 wherein at least one active ingredient is chlorhexidine gluconate (CHG).
4. The adhesive of claim 1 wherein at least one mineral oil is a USP White Mineral Oil.
5. The adhesive of claim 1 wherein at least one oil includes a liquid polymer selected from the group comprising liquid isoprene rubber, liquid butadiene rubber, liquid polyisobutylene (PIB), and combinations thereof.
6. The adhesive of claim 1 wherein the adhesive exhibits a storage modulus (G′) at a temperature of about 22° C. to about 37° C. and a frequency of about 0.01 rad/s of about 100 Pa to about 30,000 Pa.
7. The adhesive of claim 1 wherein the adhesive exhibits a storage modulus (G′) at a temperature of about 22° C. to about 37° C. and a frequency of about 100 rad/s of about 5,000 Pa to about 150,000 Pa.
8. The adhesive of claim 1 wherein the adhesive exhibits a loss modulus (G″) at a temperature of about 22° C. to about 37° C. and a frequency of about 0.01 rad/s of about 100 Pa to about 10,000 Pa.
9. The adhesive of claim 1 wherein the adhesive exhibits a loss modulus (G″) at a temperature of about 22° C. to about 37° C. and a frequency of about 100 rad/s of about 1,000 Pa to about 30,000 Pa.
10. The adhesive of claim 1 wherein the adhesive has a glass transition temperature within a range from about −70° C. to about 0° C.