Compositions comprising a compound of the avermectin family for the treatment and/or prevention of hand eczema
The present invention relates to a pharmaceutical composition comprising a compound of the avermectin family, preferably ivermectin, in a pharmaceutically acceptable carrier, for use in the treatment and/or prevention of hand eczema.
1. A method of treating and/or preventing hand eczema, comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising:
0.3% to 2% by weight, relative to the total weight of the composition, of ivermectin; and
a pharmaceutically acceptable carrier.
2. The method according to claim 1 , wherein the hand eczema is chronic hand eczema.
3. The method according to claim 1 , wherein the administering is topical application.
4. The method according to claim 1 , wherein the composition is in the form of an emulsion, of a cream, of a lotion type, of a gel or of a solution.
5. The method according to claim 1 , wherein the composition comprises from 1% to 2%, by weight, of ivermectin, relative to the total weight of the composition.
6. The method according to claim 1 , wherein the composition comprises about 0.3, 1, or 2%, by weight, of ivermectin, relative to the total weight of the composition.
7. The method according to claim 1 , wherein the composition comprises:
Ivermectin 1.0
Glycerol 4.0
Acrylate C10-30 alkyl acrylate crosspolymer 0.2
Methyl para-hydroxybenzoate 0.2
Disodium EDTA 0.05
Citric acid monohydrate 0.05
Isopropyl palmitate 4.0
Cetyl alcohol 3.5
Stearyl alcohol 2.5
Oleyl alcohol 2.0
Ceteareth-20 3.0
Sorbitan monostearate 2.0
Dimethicone 200 20 cs 0.5
Propyl para-hydroxybenzoate 0.1
Propylene glycol 2.0
Phenoxyethanol 1.0
10% sodium hydroxide qs pH
water qs 100,
as % by weight relative to the total weight of the composition.
8. The method according to claim 1 , wherein the composition comprises:
Ivermectin 0.3
Glycerol 4.0
Acrylate C10-30 alkyl acrylate crosspolymer 0.2
Methyl para-hydroxybenzoate 0.2
Disodium EDTA 0.05
Citric acid monohydrate 0.05
Isopropyl palmitate 4.0
Cetyl alcohol 3.5
Stearyl alcohol 2.5
Oleyl alcohol 2.0
Ceteareth-20 3.0
Sorbitan monostearate 2.0
Dimethicone 200 20 cs 0.5
Propyl para-hydroxybenzoate 0.1
Propylene glycol 2.0
Phenoxyethanol 1.0
10% sodium hydroxide qs pH
water qs 100,
as % by weight relative to the total weight of the composition.
9. The composition of claim 1 , wherein the concentration of ivermectin is 0.3% or 1.0% by weight, relative to the total weight of the composition.