IGURATIMOD AS AN MIF INHIBITOR
Methods of treatment of MIF-related diseases and methods of MIF inhibition are provided.
1 . A method of inhibiting macrophage migration inhibitory factor (MIF) in a subject comprising administering to the subject an amount of the following compound, or a pharmaceutically acceptable salt thereof, effective to inhibit MIF:
2 . The method of claim 1 , wherein the subject has congenital diaphragmatic hernia.
3 . A method of inhibiting macrophage migration inhibitory factor (MIF) comprising contacting the MIF with an amount of the following compound, or a pharmaceutically acceptable salt thereof, effective to inhibit MIF:
4 - 7 . (canceled)
8 . A method of reducing the dose of a steroid administered to a subject required to achieve a predetermined therapeutic effect in a disease treatable by steroid therapy, comprising administering to the subject having the disease an amount of a compound or a pharmaceutically acceptable salt of such compound effective to reduce the dose of steroid needed to achieve the therapeutic effect in the disease, wherein the compound has the following structure:
9 - 10 . (canceled)
11 . The method of claim 1 , wherein the compound is administered.
12 . The method of claim 1 , wherein the pharmaceutically acceptable salt of the compound is administered.
13 . The method of claim 1 , wherein the subject is a human.
14 . A composition comprising a pharmaceutically acceptable carrier, an amount of acetaminophen, and an amount of a compound having the structure set forth below, or a pharmaceutically acceptable salt of such compound:
15 - 17 . (canceled)
18 . A method of decreasing the likelihood of hepatotoxicity in a subject resulting from an overdose of acetaminophen, comprising administering to the subject one or more doses of the acetaminophen composition of claim 1 amounting to more than 3 g of acetaminophen in 24 hours, wherein the amount of the compound or pharmaceutically acceptable salt of such compound is effective to decrease the likelihood of hepatotoxicity in a subject resulting from an overdose of acetaminophen.
19 . (canceled)