ATG7 inhibitors and the uses thereof

1. A chemical entity which is a compound or a pharmaceutically acceptable salt of formula (I):

wherein:

R 1 is H and R 2 is H; or R 1 is H and R 2 is —OH; or R 1 is F and R 2 is H;

R a is H, I, —CN, —CO 2 CH 3 , —C(O)CH 3 , —C(S)NH 2 , —C(O)NH 2 , —S(O)CH 3 , C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 fluoroaliphatic, -T 1 -R b , R bb , —O-T 1 -R b , —O—R dd , —S-T 1 -R c , or —S—R ee ;

T 1 is absent or C 1 -C 3 alkylene optionally substituted with 1 or 2 independent occurrences of —CH 3 ,

R b is 3-7 membered cycloaliphatic; 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; 6-10-membered aryl; or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein each R b is substituted with 0-5 R d ;

R c is 3-7 membered cycloaliphatic; 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; 6-10-membered aryl; or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein each R c is substituted with 0-5 R f ;

each occurrence of R d is independently halo, —OH, —CN, —NO 2 , C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 aliphatic, —S—C 1-3 fluoroaliphatic, —N(R e ) 2 , —C(O)—N(R e ) 2 , —SO 2 CH 3 , —S(O)CH 3 , or —O—CH 2 -phenyl wherein the phenyl ring is optionally substituted with 1 or 2 independent occurrences of halo, —CN, C 1-3 aliphatic, or —O—C 1-3 aliphatic; or two occurrences of R d are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g ;

each occurrence of R f is independently halo, —OH, —CN, —NO 2 , C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 aliphatic, —S—C 1-3 fluoroaliphatic, —N(R e ) 2 , —C(O)—N(R e ) 2 , —SO 2 CH 3 , —S(O)CH 3 , or —O—CH 2 -phenyl wherein the phenyl ring is optionally substituted with 1 or 2 independent occurrences of halo, —CN, C 1-3 aliphatic, or —O—C 1-3 aliphatic; or two occurrences of R f are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g ;

R bb is C 1-3 aliphatic substituted with 0-5 R bx ;

R dd is C 1-3 aliphatic substituted with 0-5 R dx ;

R ee is C 1-3 aliphatic substituted with 0-5 R fx ;

each occurrence of R bx is independently —OH, —CN, —NO 2 , C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 aliphatic, —S—C 1-3 fluoroaliphatic, —N(R e ) 2 , —C(O)—N(R e ) 2 , —SO 2 CH 3 , —S(O)CH 3 , or —O—CH 2 -phenyl wherein the phenyl ring is optionally substituted with 1 or 2 independent occurrences of halo, —CN, C 1-3 aliphatic, or —O—C 1-3 aliphatic; or two occurrences of R bx are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R 8 ;

each occurrence of R dx is independently —Cl, —OH, —CN, —NO 2 , C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 aliphatic, —S—C 1-3 fluoroaliphatic, —N(R e ) 2 , —C(O)—N(R e ) 2 , —SO 2 CH 3 , —S(O)CH 3 , or —O—CH 2 -phenyl wherein the phenyl ring is optionally substituted with 1 or 2 independent occurrences of halo, —CN, C 1-3 aliphatic, or —O—C 1-3 aliphatic; or two occurrences of R dx are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R 8 ;

each occurrence of R fx is independently —OH, —CN, —NO 2 , C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 aliphatic, —S—C 1-3 fluoroaliphatic, —N(R e ) 2 , —C(O)—N(R e ) 2 , —SO 2 CH 3 , —S(O)CH 3 , or —O—CH 2 -phenyl wherein the phenyl ring is optionally substituted with 1 or 2 independent occurrences of halo, —CN, C 1-3 aliphatic, or —O—C 1-3 aliphatic; or two occurrences of R fx are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g ;

R g is C 1-3 aliphatic; and

R e is hydrogen or C 1-3 aliphatic.

2. The chemical entity of claim 1 , wherein R 1 is H and R 2 is H.

3. The chemical entity of claim 1 , wherein R a is I, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 fluoroaliphatic, -T 1 -R b , R bb , —O-T 1 -R b , —O—R dd , —S-T 1 -R c , or —S—R ee .

4. The chemical entity of claim 1 wherein R a is —O—C 1-3 fluoroaliphatic, or —O—R dd .

5. The chemical entity of claim 1 wherein:

R a is —S—C 1-3 fluoroaliphatic, —S-T 1 -R c , or —S—R ee ;

each occurrence of R f is independently halo, —OH, —CN, C 1-4 aliphatic, —O—C 1-3 aliphatic, —O—C 1-3 fluoroaliphatic, —N(R e ) 2 , or —C(O)—N(R e ) 2 ; or two occurrences of R f are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g ; and

each occurrence of R fx is independently —OH, —CN, C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —N(R e ) 2 , or —C(O)—N(R e ) 2 , or 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g .

6. The chemical entity of claim 1 which is a compound or a pharmaceutically acceptable salt of formulas (III-a)-(III-d):

7. The chemical entity of claim 6 , wherein R a is I, —CN, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, —S—C 1-3 fluoroaliphatic, -T 1 -R b , R bb , —O-T 1 -R b , —O—R dd , —S-T 1 -R c , or —S—R ee .

8. The chemical entity of claim 7 , wherein R a is I, —CN, C 1-3 fluoroaliphatic, —O—C 1-3 fluoroaliphatic, R bb , or O—R dd .

9. The chemical entity of claim 7 , wherein:

R a is —S—C 1-3 fluoroaliphatic or —S—R ee ;

R ee is C 1-3 aliphatic substituted with 0-2 R fx ; and

each occurrence of R fx is independently —OH, —CN, C 1-4 aliphatic, —O—C 1-3 aliphatic, C 1-3 fluoroaliphatic, —N(R e ) 2 , or —C(O)—N(R e ) 2 .

10. The chemical entity of claim 7 , wherein R a is -T 1 -R b , —O-T 1 -R b , or —S-T 1 -R c .

11. The chemical entity of claim 10 , wherein:

R a is -T 1 -R b , —O-T 1 -R b ;

T 1 is absent, —CH 2 — or —CH 2 CH 2 —; and

R b is substituted with 0-2 R d .

12. The chemical entity of claim 10 , wherein:

R a is —S-T 1 -R c ; and

T 1 is absent, —CH 2 — or —CH 2 CH 2 —.

13. The chemical entity of claim 12 , wherein:

R c is 3-7 membered cycloaliphatic or 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;

R c is substituted with 0-2 R f ;

each occurrence of R f is independently R fa ; and

R fa is halo, —OH, —CN, or C 1-4 aliphatic.

14. The chemical entity of claim 12 , wherein:

R c is a 6-10-membered aryl; or 5-10-membered heteroaryl having 1-5 heteroatoms,

R c is substituted with 0-2 R f ; and

R e is —H, —CH 3 , or —CH 2 CH 3 .

15. The chemical entity of claim 14 , wherein:

two occurrences of R f are taken together to form a 5 or 6 membered cycloaliphatic or heterocyclic ring, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, which is further optionally substituted with one occurrence of ═O and optionally substituted with one occurrence of R g ; and

R g is methyl.

16. The chemical entity of claim 14 , wherein:

each occurrence of R f is independently R fb ; and

R fb is halo, —OH, —CN, C 1-4 aliphatic, —O—C 1-3 aliphatic, —O—C 1-3 fluoroaliphatic, —N(R e ) 2 , or —C(O)—N(R e ) 2 .

17. The chemical entity of claim 14 , wherein R c is phenyl, pyridyl, furanyl or pyrazolyl optionally substituted by one occurrence of —CH 3 , —OCH 3 , or —F, and optionally substituted by one occurrence of —CH 3 , —OCH 3 , —F, —Cl, —CF 3 , or —OCF 3 .

18. The chemical entity of claim 1 , wherein the chemical entity is selected from the group consisting of:

[(2R,3S,4R,5R)-5-(4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(benzyloxy)methyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-ethoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-ethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-isopropoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(hydroxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(3-methoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-cyano-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(prop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(aminomethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-carbamoyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(3-aminoprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-vinyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(methoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate

methyl 4-amino-1-{(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoyloxy)methyl]tetrahydrofuran-2-yl}-1H-pyrazolo[3,4-d]pyrimidine-3-carboxylate;

[(2R,3S,4R,5R)-5-(3-acetyl-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1R)-1-methoxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1S)-1-methoxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1R)-1-hydroxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1S)-1-hydroxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1R)-1-hydroxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1S)-1-hydroxyethyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(2-hydroxypropan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-hydroxy-2-methylpropyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(cyanomethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(1,3-thiazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylbenzyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[4-(trifluoromethoxy)benzyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[4-(trifluoromethyl)benzyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2,4-dichlorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-methoxyethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(1H-pyrazol-4-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-phenoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(4-methoxybenzyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-methylbenzyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(3-chlorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(4-methylbenzyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(prop-2-yn-1-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(3-fluorobenzyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(pyridin-3-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-hydroxyethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1R,2R)-2-hydroxycyclohexyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1S,2S)-2-hydroxycyclohexyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(cyclopropylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(ethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(benzylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(tert-butylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1R,2R)-2-hydroxycyclopentyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1S,2S)-2-hydroxycyclopentyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2R)-2-hydroxypropyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2S)-2-hydroxypropyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2R)-2-hydroxypropyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2S)-2-hydroxypropyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(cyclobutylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(1,3-oxazol-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(pyridin-2-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-carbamothioyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1-methyl-1H-pyrazol-4-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(cyclopentylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(4-fluorobenz yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(4-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(cyclopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(pyridin-4-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(1-naphthylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(1H-pyrazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(3-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1R)-1-phenylethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1S)-1-phenylethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[3-(allyloxy)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(azetidin-3-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(5-chloro-2-furyl)methyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(2-chloroethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(benzyloxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(isobutylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[2-(dimethylamino)ethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-methyl-3-furyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(phenylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2,2,2-trifluoroethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(1-naphthylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(difluoromethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(1-hydroxycyclohexyl)methyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,4R,5R)-5-[4-amino-3-(methylsulfinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(2-phenylethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(4-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(cyanomethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(cyclohex-1-en-1-ylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2S,3R)-2-methyltetrahydrofuran-3-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2R,3R)-2-methyltetrahydrofuran-3-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2R,3S)-2-methyltetrahydrofuran-3-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-(4-amino-3-{[(2S,3S)-2-methyltetrahydrofuran-3-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,4R,5R)-5-{4-amino-3-[(methylsulfanyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2S,3S,4R,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3S,4R,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3R,4S,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(3,3-difluorocyclobutyl)methyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(difluoromethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2-methyl-3-furyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2R)-1,1,1-trifluoropropan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(6-methylpyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(cyclopentylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[2-(diethylamino)ethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(6-methoxypyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2-fluorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2,5-dimethyl-3-furyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(5-nitropyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(1-methyl-1H-imidazol-2-yl)methyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(pyridin-2-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(4-methylpyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[4-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(tert-butylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(pyridin-2-ylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(pentan-3-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(pyridin-3-ylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(cyclohexylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3R)-tetrahydrofuran-3-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3S)-tetrahydrofuran-3-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(pyridin-4-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(4-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(pyridazin-3-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(pyridazin-4-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2R)-3-methylbutan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2S)-3-methylbutan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(4-cyanopyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(1R)-2,2-difluorocyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(1S)-2,2-difluorocyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[4-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(4-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(1-methyl-1H-imidazol-5-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(cyclopropylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2R)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2S)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2R)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2S)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2R)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2S)-butan-2-ylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(1-methyl-1H-imidazol-4-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(pyridin-3-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(1R,2R)-2-methylcyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(1S,2R)-2-methylcyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(1R,2S)-2-methylcyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-({[(15,25)-2-methylcyclopropyl]methyl}sulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3-methylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(trifluoromethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2R)-1-hydroxypropan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(2S)-1-hydroxypropan-2-yl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{R 1-methyl-1H-pyrazol-4-yl)methyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(5-chloropyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(cyclobutylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(cyclobutylmethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(1R)-1-cyanoethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(1S)-1-cyanoethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(pyridin-4-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2-hydroxyethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(5-methylpyridin-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(3-cyanophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-{4-amino-3-[(2-methoxyethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-(benzylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3R,4S,5R)-5-[4-amino-3-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-4-fluoro-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(1R)-1-cyclopropylethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[(1S)-1-cyclopropylethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3R,4S,5R)-5-(4-amino-3-{[3-(trifluoromethyl)phenyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-amino-2-oxoethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1H-inden-5-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-fluoro-4-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-hydroxyethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(4-tert-butylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(cyclobutylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2,2-difluoroethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(2-naphthylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(cyclopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1-benzofuran-6-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(difluoromethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(1H-indol-3-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(ethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-fluoro-5-methoxyphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(1,3-thiazol-2-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(1,3-benzodioxol-5-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-methylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(tert-butylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-fluoro-4-methoxyphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-(4-amino-3-{[2-(dimethylamino)-2-oxoethyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(quinolin-2-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(4-isopropoxyphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1-benzofuran-5-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(4-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(cyanomethyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(5-chloropyridin-2-yl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-(4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(2-fluoro-5-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(4-methylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(pyridin-2-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3,4-dimethylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-(4-amino-3-{[4-(trifluoromethoxy)phenyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-(4-amino-3-{[3-(trifluoromethoxy)phenyl]sulfanyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3-methoxyphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(cyclopropylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(6-fluoro-2,3-dihydro-1H-inden-5-yl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(1-benzothiophen-2-ylmethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3-methylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(3,4-dimethoxyphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2R,3S,5R)-5-{4-amino-3-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(2-naphthylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(2-fluoro-4-methylphenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-(4-amino-3-ethyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(ethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(4-methylphenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(2-fluorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(2,3-dihydro-1H-inden-5-ylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2S,3S,5R)-5-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

{(2S,3S,5R)-5-[4-amino-3-(benzylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(5-chloropyridin-2-yl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(4-fluorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-{4-amino-3-[(3-chlorophenyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-(4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate;

[(2S,3S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate; and

[(2S,3S,5R)-5-{4-amino-3-[(2,2-difluoroethyl) sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3-hydroxytetrahydrofuran-2-yl]methyl sulfamate, or a pharmaceutically acceptable salt thereof.

19. A pharmaceutical composition comprising a chemical entity of claim 1 , and a pharmaceutically acceptable carrier.