Compositions and methods for blocking ultraviolet radiation
View Patent ↗The present disclosure relates to compositions capable of absorbing UVA and UVB light. In particle, the present disclosure relates to UV screening compositions comprising at least a portion of LITE-1 polypeptides which are capable of absorbing UV light (e.g., UV-A and/or UV-B light).
1. A composition comprising:
a) a LITE-1 polypeptide or a portion thereof wherein said LITE-1 polypeptide or portion thereof comprises one or more mutations, wherein said mutations comprise S226F and/or A332V and are capable of absorbing UV light; and b) at least one carrier.
2. The composition of claim 1 , wherein said LITE-1 is at least 90% identical to SEQ ID NO: 1 and wherein said mutations comprise S226F and/or A332V.
3. The composition of claim 1 , wherein said mutations are not W77 or W328.
4. The composition of claim 1 , wherein said carrier is a pharmaceutically acceptable carrier.
5. The composition of claim 1 , wherein said carrier comprises one or more carriers selected from the group consisting of preservatives, emollients, emulsifying agents, surfactants, moisturizers, gelling agents, thickening agents, conditioning agents, film-forming agents, stabilizing agents, anti-oxidants, texturizing agents, gloss agents, mattifying agents, solubilizers, pigments, dyes, and fragrances.
6. The composition of claim 1 , wherein said composition is selected from the group consisting of a pharmaceutical composition, a cosmetic composition, a sunscreen, a moisturizer, a gel, an ointment, a stick, a cream, and a lotion.
7. The composition of claim 1 , wherein said composition is formulated for topical administration.
8. A method of protecting skin against UVA and/or UVB light, comprising:
contacting skin of a subject with a composition of claim 1 .