Granted Patent
B2
US 10,870,677 · App. 16/365,123 · Granted Dec 22, 2020
Compositions and methods for treating CNS disorders
Inventors:
Gabriel Martinez Botella (Wayland, MA); Francesco G. Salituro (Marlborough, MA); Albert Jean Robichaud (Boston, MA); Boyd L. Harrison (Princeton Junction, NJ)
Assignee:
Sage Therapeutics, Inc.
C07J43/003A61K9/0019A61K9/0053A61K31/58A61P25/00C07D231/14C07D249/04C07D249/18C07D295/033C07J13/007C07J75/00
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Abstract
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable said thereof; wherein, R 1 , R 2a , R 2b , R 3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
Claims (3)
1. A process for preparing a compound of Formula (A14):
the process comprising, treating a compound of Formula (A13):
with trimethyl(trifluoromethyl)silane and tetra-n-butylammonium fluoride, wherein the process is performed in tetrahydrofuran at room temperature.
Assignments (2)
CHANGE OF NAME
Recorded Apr 23, 2026
From: SAGE THERAPEUTICS, INC.
To: SAGE THERAPEUTICS, LLC
Reel/Frame 075472/0569 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 2, 2020
From: BOTELLA, GABRIEL MARTINEZ; SALITURO, FRANCESCO G.; ROBICHAUD, ALBERT JEAN; HARRISON, BOYD L.
To: SAGE THERAPEUTICS, INC.
Reel/Frame 054236/0801 →
Continuity (3)
Continuation
15519478
Provisional Application
62064957
· Oct 16, 2014