Devices, systems, and methods to evaluate cardiovascular function
Devices and methods are disclosed which relate to the detection of cardiovascular efficiency and risk of disease. The rate of volumetric change of the heart can be determined by measuring the parallel conductance across electrodes attached to the heart. Measurements from a lumen would consider the total conductance. The rate of volumetric or lumen cross-section area change can then be compared to an average model to determine the health of a patient.
1. A method of determining an index of heart function, the method comprising the steps of:
introducing an impedance device into a pericardial space on the surface of a heart, the impedance device comprising a first excitation electrode, a second excitation electrode, a first detection electrode, and a second detection electrode;
measuring a total conductance during a cardiac cycle using the first detection electrode and the second detection electrode, the total conductance including a parallel conductance and indicative of conductance of a heart wall, conductance of a ventricle adjacent to the heart wall, and conductance within the pericardial space; and
generating an efficiency model of the heart from the total conductance, the total conductance including the parallel conductance.
2. The method of claim 1 , wherein the step of measuring total conductance during a cardiac cycle is performed from within the pericardial space.
3. The method of claim 2 , wherein the step of measuring total conductance during a cardiac cycle includes the step of obtaining a parallel conductance measurement, and the step of generating an efficiency model of the heart includes the step of generating an efficiency model of the heart from the parallel conductance measurement.
4. The method of claim 3 , wherein the step of generating an efficiency model further comprises the step of comparing the total conductance to a rate of volumetric change of the heart.
5. The method of claim 3 , wherein the step of measuring a total conductance comprises multiple total conductance measurements to determine the volume of the heart.
6. The method of claim 3 , wherein the step of measuring a total conductance comprises the use of a conductance reader operably coupled to the impedance device.
7. The method of claim 3 , wherein the step of generating an efficiency model further comprises the step of evaluating the maximum rate of volumetric change of the heart.
8. The method of claim 1 , further comprising the step of calculating a max rate of change of a cross sectional area of the heart based on the measured total conductance; and
wherein the step of generating an efficiency model of the heart further comprises generating an efficiency model of the heart from the calculated max rate of change of the cross sectional area.
9. A method of determining an index of heart function, the method comprising the steps of:
introducing an impedance device into a lumen of a heart, the impedance device comprising a first excitation electrode, a second excitation electrode, a first detection electrode, and a second detection electrode;
measuring a parallel conductance from within the lumen of the heart during a cardiac cycle using the first detection electrode and the second detection electrode;
generating an efficiency model of the heart from the parallel conductance measurement.
10. The method of claim 9 , further comprising the step of calculating a max rate of change of a cross sectional area of the heart based on the measured parallel conductance; and
wherein the step of generating an efficiency model of the heart further comprises generating an efficiency model of the heart from the calculated max rate of change of the cross sectional area.
11. The method of claim 9 , wherein the step of generating an efficiency model further comprises the step of comparing the parallel conductance to a rate of volumetric change of the heart.
12. The method of claim 9 , wherein the step of measuring a parallel conductance comprises multiple parallel conductance measurements to determine the volume of the heart.
13. The method of claim 9 , wherein the step of measuring a parallel conductance comprises the use of a conductance reader operably coupled to the impedance device.
14. The method of claim 9 , wherein the step of generating an efficiency model further comprises the step of evaluating the maximum rate of volumetric change of the heart.
15. A method of determining an index of vessel function, the method comprising the steps of:
introducing an impedance device into a lumen of a vessel, the impedance device comprising a first excitation electrode, a second excitation electrode, a first detection electrode, and a second detection electrode;
measuring a parallel conductance from the lumen of the vessel during a cardiac cycle using the first detection electrode and the second detection electrode;
calculating a max rate of change of a cross sectional area of the vessel based on the measured parallel conductance;
generating an efficiency model of the vessel from the parallel conductance measurement and the calculated max rate of change of the cross sectional area; and
generating an efficiency model of the heart from the parallel conductance measurement.
16. The method of claim 15 , further comprising the step of calculating a max rate of change of a cross sectional area of the vessel based on the measured parallel conductance; and
wherein the step of generating an efficiency model of the vessel further comprises generating an efficiency model of the heart from the calculated max rate of change of the cross sectional area.
17. The method of claim 15 , wherein the step of generating an efficiency model further comprises the step of comparing the parallel conductance to a rate of volumetric change of the vessel.
18. The method of claim 15 , wherein the step of measuring a parallel conductance comprises a single parallel conductance measurement.
19. The method of claim 15 , wherein the step of measuring a parallel conductance comprises the use of a conductance reader operably coupled to the impedance device.
20. The method of claim 15 , wherein the step of generating an efficiency model further comprises the step of evaluating the maximum rate of volumetric change of the vessel.