Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases
View Patent ↗Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form, can be used to treat or alleviate pain or related conditions, such as complex regional pain syndrome.
1. A method of treating pain in a human being suffering from complex regional pain syndrome (CRPS) and insomnia comprising administering, in one or more individual intravenous doses for a total amount of about 20 mg to about 2000 mg of neridronic acid, in an acid form or a salt form, or in one or more individual oral doses for a total amount of about 4000 mg to about 40,000 mg of neridronic acid, in the acid form or the salt form, to the human being suffering from CRPS and insomnia, with the result that 12 weeks from the first day that the neridronic acid is administered to the human being, the human being has an average pain intensity score, according to the 0-10 numerical rating scale (NRS), that is at least about 10% lower than the average pain intensity score at baseline.
2. The method of claim 1 , wherein the CRPS is CRPS Type-I.
3. The method of claim 1 , wherein the CRPS is CRPS Type-II.
4. The method of claim 1 , wherein the CRPS is warm CRPS.
5. The method of claim 1 , wherein the CRPS is cold CRPS.
6. The method of claim 1 , wherein the CRPS is triggered by a traumatic event.
7. The method of claim 6 , wherein the traumatic event is a bone fracture.
8. The method of claim 6 , wherein the traumatic event is a surgery.
9. The method of claim 6 , wherein the traumatic event is a soft tissue injury.
10. The method of claim 6 , wherein the traumatic event is a bone injury.
11. The method of claim 6 , wherein the traumatic event is a nerve injury.
12. The method of claim 6 , wherein the traumatic event is a sprain.
13. The method of claim 6 , wherein the traumatic event is a crush.
14. The method of claim 6 , wherein the traumatic event is a contusion.
15. The method of claim 6 , wherein the traumatic event is a dislocation.
16. The method of claim 6 , wherein the traumatic event is a scratch.
17. The method of claim 6 , wherein the traumatic event is a skin puncture.
18. The method of claim 1 , wherein on the day before the neridronic acid is first administered, the human being has an average pain intensity score of at least 5 on the 0-10 NRS.
19. The method of claim 1 , wherein on the day before the neridronic acid is first administered, the human being has an average pain intensity score of at least 6 on the 0-10 NRS.
20. The method of claim 1 , wherein on the day before the neridronic acid is first administered, the human being has an average pain intensity score of at least 7 on the 0-10 NRS.
21. The method of claim 1 , wherein on the day before the neridronic acid is first administered, the human being has an average pain intensity score of at least 8 on the 0-10 NRS.
22. The method of claim 1 , wherein on the day before the neridronic acid is first administered, the human being has an average pain intensity score of at least 9 on the 0-10 NRS.
23. The method of claim 1 , wherein at 12 weeks from the first day that the neridronic acid is administered to the human being, the human being has an average pain intensity score that is at least about 30% lower than the average pain intensity score at baseline.
24. The method of claim 1 , wherein at 12 weeks from the first day that the neridronic acid is administered to the human being, the human being has an average pain intensity score that is at least about 50% lower than the average pain intensity score at baseline.
25. The method of claim 1 , wherein the human being has suffered from the CRPS for less than 2 years on the first day that the neridronic acid is administered to the human being.
26. The method of claim 1 , wherein the human being has suffered from the CRPS for about 2 years to about 4 years on the first day that the neridronic acid is administered to the human being.
27. The method of claim 1 , wherein the human being has suffered from the CRPS for about 4 years to about 6 years on the first day that the neridronic acid is administered to the human being.
28. The method of claim 1 , wherein the human being has suffered from the CRPS for about 6 years to about 10 years on the first day that the neridronic acid is administered to the human being.