PRECISION RECHARGING USING PATIENT PRE-DIALYSIS BUN LEVELS
The invention relates to devices, systems, and methods for recharging zirconium phosphate. The devices, system, and methods use a patient pre-dialysis BUN level to set one or more recharge parameters for recharging the zirconium phosphate. The devices, systems, and methods allow for precision recharging of the zirconium phosphate based on the patient pre-dialysis BUN level.
1 . A system comprising:
a recharging flow path comprising one or more recharge solution sources; the one or more recharge solution sources fluidly connectable to an inlet of a zirconium phosphate sorbent module containing zirconium phosphate; and at least one pump for introducing one or more recharge solutions from the one or more recharge solution sources through the zirconium phosphate sorbent module; and
a processor, the processor programmed to set one or more recharge parameters to recharge the zirconium phosphate within the sorbent module based on a patient pre-dialysis BUN level.
2 . The system of claim 1 , wherein the one or more recharge solution sources comprise a brine source and a water source.
3 . The system of claim 1 or 2 , wherein the one or more recharge parameters comprise at least one of: time of recharging, recharge temperature, volume of at least one recharge solution, concentration of at least one recharge solution, and combinations thereof.
4 . The system of any of claims 1 - 3 , wherein the processor sets a volume of the one or more recharge solutions using an equation: Volume=A*Pre-BUN+B; wherein A and B are based on patient pre-dialysis solute level and a concentration of the one or more recharge solutions.
5 . The system of any of claims 1 - 3 , wherein the processor is programmed to set the volume of the one or more recharge solutions based on the patient pre-dialysis BUN level and a concentration of the one or more recharge solutions.
6 . The system of any of claims 1 - 3 , wherein the processor is programmed to set the concentration of the one or more recharge solutions based on the patient pre-dialysis BUN level, and a volume of the one or more recharge solutions to be used.
7 . The system of any of claims 1 - 6 , further comprising at least one ammonia sensor in an effluent line fluidly connectable to an outlet of the zirconium phosphate sorbent module; wherein the processor is programmed to estimate the patient pre-dialysis BUN level based on an ammonia concentration in an effluent from the zirconium phosphate sorbent module.
8 . The system of claim 7 , wherein the processor is programmed to estimate the patient pre-dialysis BUN level based on a comparison of the ammonia concentration in the effluent with a known ammonia measurement curve.
9 . The system of any of claims 1 - 8 , wherein the processor is programmed to receive a patient pre-dialysis BUN level from a user.
10 . The system of any of claims 1 - 6 , further comprising a reader in communication with the processor, the reader receiving the patient pre-dialysis BUN level from a readable component on or in the sorbent module.
11 . A method, comprising the steps of:
recharging zirconium phosphate within a zirconium phosphate sorbent module by introducing one or more recharge solutions from one or more recharge solution sources through the zirconium phosphate sorbent module with one or more recharge parameters;
wherein the one or more recharge parameters are set based on a patient pre-dialysis BUN level.
12 . The method of claim 11 , wherein the one or more recharge parameters comprise at least one of: time of recharging, recharge temperature, volume of at least one recharge solution, concentration of at least one recharge solution, and combinations thereof.
13 . The method of claim 11 or 12 , wherein the one or more recharge solution sources comprise a brine source and a water source.
14 . The method of any of claims 11 - 13 , further comprising the step of estimating the patient pre-dialysis BUN level based on an ammonia sensor in an effluent line fluidly connected to an outlet of the zirconium phosphate sorbent module.
15 . The method of any of claims 11 - 13 , further comprising the step of estimating the patient pre-dialysis BUN level based on one or more sensors in a dialysate flow path.
16 . The method of any of claims 11 - 13 , further comprising the step of receiving the patient pre-dialysis BUN level from a user.
17 . The method of any of claims 11 - 16 , wherein setting the recharge parameters comprises setting the concentration of the one or more recharge solutions based on the patient pre-dialysis BUN level and a volume of the one or more recharge solutions to be used.
18 . The method of any of claims 11 - 16 , wherein setting the recharge parameters comprises setting the volume of the one or more recharge solutions based on the patient pre-dialysis BUN level and a concentration of the one or more recharge solutions.
19 . The method of any of claims 11 - 16 , wherein setting the recharge parameters comprises setting the volume of the one or more recharge solutions using an equation volume=A*Pre-BUN+B; wherein A and B are based on patient pre-dialysis solute levels and a concentration of the one or more recharge solutions.
20 . The method of any of claims 11 - 19 , wherein the method is performed by a processor of a sorbent recharger.