IP Library Granted Patent US 10,682,490
Granted Patent B2
US 10,682,490 · App. 16/375,393 · Granted Jun 16, 2020

Methods and devices for providing a stimulus to a subject to induce gamma oscillations

Inventors: Li-Huei Tsai (Cambridge, MA); Emery Brown (Brookline, MA); Hannah Iaccarino (Somerville, MA); Anthony James Martorell (Cambridge, MA); Chinnakkaruppan Adaikkan (Somerville, MA)
Assignee: Massachusetts Institute of Technology
A61M21/00A61H23/00A61N5/062A61N5/0622A61M2021/0022A61M2021/0027A61M2021/0044A61N5/0618A61N2005/063A61N2005/0651A61N2005/0662
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Quick Facts
Patent No.
US 10,682,490
App. No.
16/375,393
Granted
Jun 16, 2020
Kind
B2
Abstract

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

Claims (44)

1. A method, comprising:

A) administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

2. The method of claim 1 , wherein the synchronized gamma oscillations have a frequency of about 40 Hz.

3. The method of claim 1 , wherein the subject is a human.

4. The method of claim 1 , wherein A) comprises:

improving cognitive function in the subject via administering the non-invasive stimulus to the subject to induce the synchronized gamma oscillations in the at least one brain region of the subject.

5. The method of claim 1 , wherein A) comprises:

maintaining or enhancing memory association in the subject via administering the non-invasive stimulus to the subject to induce the synchronized gamma oscillations in the at least one brain region of the subject.

6. The method of claim 1 , wherein A) comprises:

maintaining or enhancing cognitive flexibility in the subject via administering the non-invasive stimulus to the subject to induce the synchronized gamma oscillations in the at least one brain region of the subject.

7. The method of claim 1 , wherein A) comprises:

reducing anxiety in the subject via administering the non-invasive stimulus to the subject to induce the synchronized gamma oscillations in the at least one brain region of the subject.

8. A device, comprising:

a signal generator to generate a signal having a frequency of approximately 35 Hz to approximately 45 Hz; and

an emitter, coupled to the signal generator, to administer a stimulus non-invasively to a subject, based on the signal generated by the signal generator, to induce synchronized gamma oscillations in at least one brain region of the subject in response to the stimulus.

9. The device of claim 8 , wherein the emitter is a light emitter.

10. The device of claim 9 , wherein the light emitter is selected from the group consisting of a fiber-optic based emitter and a solid-state emitter.

11. The device of claim 10 , wherein the light emitter is a solid-state emitter and includes at least one light emitting diode (LED).

12. The device of claim 9 , wherein the emitter includes a display screen.

13. The device of claim 8 , wherein the emitter is a sound emitter.

14. The device of claim 13 , wherein the stimulus is an audible click train.

15. The device of claim 8 , wherein the emitter is a haptic emitter and the stimulus is a haptic stimulus.

16. A method, comprising:

A) providing a device that administers a non-invasive stimulus to a subject during use of the device, wherein the non-invasive stimulus has a frequency of approximately 35 Hz to approximately 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

17. The method of claim 16 , wherein the device includes:

a signal generator to generate a signal; and

an emitter, coupled to the signal generator, to administer the non-invasive stimulus non-invasively to the subject, based on the signal generated by the signal generator, to induce the synchronized gamma oscillations in the at least one brain of the subject.

18. The method of claim 17 , wherein the emitter is a light emitter.

19. The method of claim 18 , wherein the light emitter is selected from the group consisting of a fiber-optic based emitter and a solid-state emitter.

20. The method of claim 19 , wherein the light emitter is a solid-state emitter and includes at least one light emitting diode (LED).

21. The method of claim 17 , wherein the emitter includes a display screen.

22. The method of claim 17 , wherein the emitter is a sound emitter.

23. The method of claim 22 , wherein the stimulus is an audible click train.

24. The method of claim 16 , wherein the stimulus is a haptic stimulus.

25. A method, comprising:

A) controlling an emitter to expose a subject to a non-invasive stimulus generated by the emitter and having a frequency of approximately 35 Hz to approximately 45 Hz, such that synchronized gamma oscillations are induced in at least one brain region of the subject.

26. The method of claim 25 , wherein the emitter is a light emitter, and wherein A) comprises:

controlling the light emitter to expose the subject to a light stimulus as the non-invasive stimulus.

27. The method of claim 25 , wherein the emitter is a sound emitter, and wherein A) comprises:

controlling the sound emitter to expose the subject to a sound stimulus as the non-invasive stimulus.

28. The method of claim 25 , wherein the emitter is a haptic emitter, and wherein A) comprises:

controlling the haptic emitter to expose the subject to a haptic stimulus as the non-invasive stimulus.

29. The method of claim 25 , wherein A) comprises:

executing one or more computer-executable instructions to control the emitter.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2019
From: TSAI, LI-HUEI; BROWN, EMERY; IACCARINO, HANNAH; MARTORELL, ANTHONY JAMES; ADAIKKAN, CHINNAKKARUPPAN
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 049356/0506 →
Continuity (3)
Continuation 15360637 · Nov 23, 2016
Provisional Application 62259187 · Nov 24, 2015
Related Publication 20190240443A1 · Aug 8, 2019
Cited By (7)
US 12,296,106 US 12,311,194 US 12,318,549 US 12,383,759 US 12,434,072 US 12,515,069 US 12,678,089