IP Library › Patent Application 16375750
Patent Application
App. No. 16/375,750

COMPOSITIONS CONTAINING ALPHA-2-ADRENERGIC AGONIST COMPONENTS

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Patent No.
US None
App. No.
16/375,750
Abstract

Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.

Claims (12)

1 . A therapeutically effective aqueous ophthalmic composition comprising:

a solution containing 0.1% (w/v) of a compound selected from the group consisting of brimonidine, a salt of brimonidine, and an ester of brimonidine,

wherein the solution further comprises an oxy-chloro preservative and carboxymethylcellulose,

wherein the composition has a pH between 7.0-8.0.

2 . The composition of claim 1 which comprises about 0.1% (w/v) of brimonidine tartrate.

3 . The composition of claim 1 which comprises 0.1% (w/v) of brimonidine tartrate.

4 . The composition of either of claim 3 wherein the carboxymethyl cellulose enhances the solubility of brimonidine tartrate in solution.

5 . The composition of claim 3 wherein the oxy-chloro component is Purite.

6 . The composition of claim 3 further comprising boric acid.

7 . The composition of claim 3 further comprising sodium borate.

8 . The composition of claim 3 further comprising hydrochloric acid.

9 . The composition of claim 8 wherein the composition has a pH of 7.4-8.0.