Devices for therapeutic nasal neuromodulation and associated methods and systems
Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.
1. A device for treating a condition within a nasal cavity of a patient, the device comprising:
a plurality of individual and flexible struts that cooperatively define a deformable frame, wherein the frame is transformable between a low-profile delivery state, to facilitate delivery of the frame to a target site within a nasal cavity of a patient, and an expanded state; and
a retractable and deployable micro-electrode array arranged about the plurality of struts,
wherein each of the plurality of struts comprises at least one electrode of the micro-electrode array, such that, when in the expanded state, at least some of the struts place corresponding electrodes into direct contact with target tissue at respective multiple locations at the target site within the nasal cavity, wherein at least some of the electrodes of the micro-electrode array are individually activatable in response to receipt of activation signals from a controller operably coupled to the micro-electrode array and configured to control output of energy therefrom, such that electrodes in direct contact with the target tissue are configured to emit radiofrequency (RF) energy based, at least in part, on neural and anatomical detection and mapping and at a power sufficient to cause multiple and separate points of disruption of neural activity along neural fibers innervating nasal mucosa within the nasal cavity.
2. The device of claim 1 , wherein the plurality of struts form a frame comprising a circumferential geometry when in the expanded state.
3. The device of claim 2 , wherein the plurality of struts comprises at least three struts spaced radially apart when in the expanded state.
4. The device of claim 2 , wherein the electrode array is configured to provide circumferential delivery of energy when in the expanded state.
5. The device of claim 1 , wherein the plurality of struts comprise deformable wires.
6. The device of claim 5 , wherein the deformable wires comprise shape memory material.
7. The device of claim 1 , wherein each strut comprises at least two electrodes of the electrode array.
8. The device of claim 7 , wherein each strut comprises multiple electrodes of the electrode array positioned at separate and discrete portions of the strut.
9. The device of claim 1 , wherein, when in the expanded state, each strut positions at least one associated electrode of the electrode array relative to a separate respective location of the multiple locations for delivery of energy thereto.
10. The device of claim 9 , wherein each strut positions at least one associated electrode of the electrode array into contact with tissue at a respective location of the multiple locations for delivery of energy thereto.
11. The device of claim 10 , wherein the electrodes of the electrode array are configured to deliver RF energy to tissue at respective locations within the nasal cavity, wherein the respective locations are associated with parasympathetic nerve supply.
12. The device of claim 11 , wherein the electrodes of the electrode array are configured to deliver RF energy at a level sufficient to therapeutically modulate postganglionic parasympathetic nerves.
13. The device of claim 12 , wherein the multiple locations are within a nasal cavity proximate or inferior to the sphenopalatine foramen.
14. The device of claim 13 , wherein the electrodes of the electrode array are configured to deliver RF energy at a level sufficient to therapeutically modulate postganglionic parasympathetic nerves innervating nasal mucosa at microforamina of a palatine bone of the patient.
15. The device of claim 12 , wherein the condition is selected from the group consisting of allergic rhinitis, non-allergic rhinitis, chronic rhinitis, acute rhinitis, chronic sinusitis, acute sinusitis, chronic rhinosinusitis, acute rhinosinusitis, and medical resistant rhinitis.
16. The device of claim 1 , wherein the struts, when in the expanded deployed state, are sized to contact the multiple locations within the nasal cavity to thereby anchor the electrode array in position within the nasal cavity and further position portions thereof relative to respective locations for delivery of energy thereto.
17. The device of claim 1 , further comprising a controller operably coupled to the electrode array and configured to control energy output from one or more of the electrodes of the electrode array.
18. The device of claim 1 , further comprising a mechanism for transforming the electrode array and struts between the low-profile delivery state and the expanded deployed state.