DLL3 MODULATORS AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
1 .- 20 . (canceled)
21 . A nucleic acid encoding a humanized light chain variable region, wherein the light chain variable region is 70% identical to SEQ ID NO: 30.
22 . The nucleic acid of claim 21 , wherein the light chain variable region is 80% identical to SEQ ID NO: 30.
23 . The nucleic acid of claim 21 , wherein the light chain variable region is 90% identical to SEQ ID NO: 30.
24 . The nucleic acid of claim 21 , wherein the light chain variable region is 100% identical to SEQ ID NO: 30.
25 . A vector comprising the nucleic acid of claim 21 .
26 . A vector comprising the nucleic acid of claim 22 .
27 . A vector comprising the nucleic acid of claim 23 .
28 . A vector comprising the nucleic acid of claim 24 .
29 . A host cell comprising the nucleic acid of claim 21 .
30 . A host cell comprising the vector of claim 25 .
31 . A nucleic acid encoding a humanized heavy chain variable region, wherein the heavy chain variable region is 70% identical to SEQ ID NO: 31.
32 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 80% identical to SEQ ID NO: 31.
33 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 90% identical to SEQ ID NO: 31.
34 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 100% identical to SEQ ID NO: 31.
35 . A vector comprising the nucleic acid of claim 31 .
36 . A vector comprising the nucleic acid of claim 32 .
37 . A vector comprising the nucleic acid of claim 33 .
38 . A vector comprising the nucleic acid of claim 34 .
39 . A host cell comprising the nucleic acid of claim 31 .
40 . A host cell comprising the vector of claim 35 .