Inorganic and organic mass spectrometry systems and methods of using them
Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.
1. A method of sequentially detecting inorganic ions and organic ions using a mass analyzer fluidically coupled to an ionization core, the method comprising sequentially selecting (i) ions from the inorganic ions received from the ionization core and (ii) ions from the organic ions received from the ionization core, in which the mass analyzer comprises a first single core mass spectrometer and a second single core mass spectrometer each configured to use a common processor, a common power source and at least one common vacuum pump, wherein the first single core mass spectrometer is configured to select the ions from the inorganic ions received from the ionization core and the second single core mass spectrometer is configured to select the ions from the organic ions received from the ionization core.
2. The method of claim 1 , further comprising providing the selected inorganic ions from the first single core mass spectrometer to a first detector during a first analysis period.
3. The method of claim 2 , further comprising providing the selected organic ions from the second single core mass spectrometer to the first detector during a second analysis period different from the first analysis period.
4. The method of claim 1 , further comprising providing the selected inorganic ions from the first single core mass spectrometer to a first detector during a first analysis period and providing the selected organic ions from the second single core mass spectrometer to a second detector during the first analysis period.
5. The method of claim 1 , further comprising providing ions to the first single core mass spectrometer during a first analysis period while preventing ion flow to the second single core mass spectrometer during the first analysis period.
6. The method of claim 5 , further comprising providing ions to the second single core mass spectrometer during a second analysis period while preventing ion flow to the first single core mass spectrometer during the second analysis period.
7. The method of claim 6 , further comprising configuring the ionization core with an inorganic ion source and an organic ion source separate from the inorganic ion source.
8. The method of claim 7 , further comprising providing ions from the inorganic ion source to the first single core mass spectrometer during a first analysis period while preventing ion flow from the organic ion source to the second single core mass spectrometer during the first analysis period.
9. The method of claim 7 , further comprising providing ions from the organic ions source to the second single core mass spectrometer during a second analysis period while preventing ion flow from the inorganic ion source to the first single core mass spectrometer during the second analysis period.
10. The method of claim 1 , further comprising configuring the mass analyzer with an interface configured to provide ions to a detector from only one of the first single core mass spectrometer and the second single core mass spectrometer during a first analysis period.
11. A method of sequentially detecting inorganic ions and organic ions using a mass analyzer fluidically coupled to an ionization core, the method comprising sequentially selecting (i) ions from the inorganic ions received from the ionization core and (ii) ions from the organic ions received from the ionization core, in which the mass analyzer comprises a dual core mass spectrometer configured to select both the inorganic ions and the organic ions.
12. The method of claim 11 , further comprising providing the selected inorganic ions from the dual core mass spectrometer to a first detector during a first analysis period.
13. The method of claim 12 , further comprising providing the selected organic ions from the dual core mass spectrometer to the first detector during a second analysis period different from the first analysis period.
14. The method of claim 11 , further comprising providing the selected inorganic ions from the dual core mass spectrometer to a first detector during a first analysis period and providing the selected organic ions from the dual core mass spectrometer to a second detector during a second analysis period.
15. The method of claim 11 , further comprising providing inorganic ions to the dual core mass spectrometer during a first analysis period while preventing organic ion flow to the dual core mass spectrometer during the first analysis period.
16. The method of claim 15 , further comprising providing organic ions to the dual core mass spectrometer during a second analysis period while preventing inorganic ion flow to the dual core mass spectrometer during the second analysis period.
17. The method of claim 16 , further comprising configuring the ionization core with an inorganic ion source and an organic ion source separate from the inorganic ion source.
18. The method of claim 17 , further comprising configuring the dual core mass spectrometer co to comprise a dual quadrupole assembly.
19. The method of claim 17 , further comprising configuring the dual core mass spectrometer to comprise a dual quadrupole assembly fluidically coupled to a first detector through an interface and fluidically coupled to a second detector through the interface and a quadrupole assembly.
20. The method of claim 19 , further comprising configuring the interface to comprise a non-coplanar interface.