Use of ultrarapid acting insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
1. A method of treating a patient with diabetes having a pre-meal blood glucose level greater than 100 mg/dl comprising:
administering a split dose of an ultrarapid acting insulin formulation, the split dose including an initial dose taken at mealtime and a second dose of between 10% to 100% of the initial dosage taken 30 to 150 minutes after beginning a meal;
wherein the pre-meal blood glucose level for a next meal is greater than 140 mg/dl.
2. The method of claim 1 , wherein the second dose is taken 60-150 minutes after beginning a meal.
3. The method of claim 2 , wherein the second dose is taken 90-150 minutes after beginning a meal.
4. The method of claim 1 , wherein the pre-meal blood glucose level is greater than 100 mg/dl for at least three pre-meal blood glucose readings taken within 10 days.
5. The method of claim 4 , wherein the pre-meal blood glucose level is greater than 100 mg/dl for at least three pre-meal blood glucose readings taken within 5 days.
6. A method of treating hyperglycemia in a patient whose pre-meal blood glucose is greater than 140 mg/dl, comprising:
administering an initial dose of an ultrarapid acting insulin formulation before a meal or at mealtime, and
administering a secondary dose of the ultrarapid acting insulin formulation 30 to 120 minutes after the initial dose comprising between 10% to 100% of the initial dose, wherein the secondary dose is titrated so that median blood glucose 1 to 2 hours after the secondary dose is less than 180 mg/dl.
7. The method of claim 6 , wherein the secondary dose is administered to a patient in which increasing the dosage of the mealtime dose produces an undesirably lesser, non-proportional reduction in blood glucose as compared to an unincreased mealtime dosage.
8. The method of claim 6 , wherein the ultrarapid acting insulin formulation comprises 3,6-di(succinyl-4-aminobutyl)-, 3,6-di(maleyl-4-aminobutyl)-, 3,6-di(glutaryl-4-aminobutyl)-, 3,6-di(malonyl-4-aminobutyl)-, 3,6-di(oxalyl-4-aminobutyl)-, or 3,6-di(fumaryl-4-aminobutyl)-2,5-diketopiperazine.
9. The method of claim 8 , wherein the ultrarapid acting insulin formulation comprises 3,6-di(fumaryl-4-aminobutyl)-2,5-diketopiperazine.
10. The method of claim 9 , wherein the ultrarapid acting insulin formulation comprises human insulin.
11. The method of claim 10 , wherein the ultrarapid acting insulin formulation is administered by inhalation.