Triazole ACC inhibitors and uses thereof
The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
1. A compound of formula:
or a pharmaceutically acceptable salt or agriculturally acceptable salt thereof, wherein:
R 1 is —CH 3 , —CHCF 2 , or —CF 3 ;
R 3 is
R 9 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, tertiary butyl, —CH 2 CH 2 OH, —CH 2 CCH, —CH 2 CH 2 CCH, —CH 2 CHCH 2 , —CH 2 CHC(CH 3 ) 2 , —CH 2 CN, —CH 2 CH 2 CN, —COCH 3 , —CH 2 -cyclopropyl, —CH 2 CH 2 SCH 3 , —CH 2 CH 2 OCH 3 , —CH 2 CH 2 COOCH 3 , —CH 2 COOCH 3 , —COOCH 3 , —CH 2 CH 2 SO 2 CH 3 , —CH 2 CONH 2 ,
R 4 is
wherein X is H, F, Cl, Br, CN, CF 3 , methyl, ethyl, isopropyl, cyclopropyl, —SO 2 Me, —OCF 2 H, —CF 2 H, —OCF 3 , or —OCF 2 H, Y is optionally substituted alkyl, cyanomethyl, cyanoethyl, or methoxyethyl, and T is independently H, F, Cl, or methyl; and
L 1 is —CH(CH 3 ), —C(CH 3 ) 2 , or —CH 2 .
2. A compound of formula:
or a pharmaceutically acceptable salt or agriculturally acceptable salt thereof.
3. A compound of formula:
or a pharmaceutically acceptable salt or agriculturally acceptable salt thereof.