Liquid drug cartridges and associated dispenser
Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.
1. A method of delivering an aerosolized medication to a user's respiratory system, comprising:
detecting an inhalation by a user using an inhalation monitoring system;
communicating a signal to a piston actuation system, the signal indicating that the inhalation has been detected;
in response to receiving the signal, displacing, using the piston actuation system, a piston that is positioned at a distal end of a reservoir of a cartridge to force a volume of liquid medicament from the reservoir of the cartridge;
filtering the volume of liquid medicament using a filter element positioned within an end cap of the cartridge that is positioned on a proximal end of the reservoir, the proximal end being on an opposite side of the reservoir as the distal end;
ejecting the volume of liquid medicament onto a rear face of a mesh of an aerosol generator via an ejection opening of the end cap after the volume of liquid medicament has been filtered;
vibrating the mesh of the aerosol generator to aerosolize the volume of liquid medicament to produce a plume of aerosolized medicament; and
entraining the aerosolized medicament within inspiratory flow through a mouthpiece of an inhaler.
2. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , further comprising:
interfacing the cartridge with a housing of the inhaler prior to displacing the piston.
3. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , further comprising:
removing a removable cap from the end cap to expose the ejection opening, wherein the removable cap is configured to interface with the end cap such that the ejection opening is closed by the removable cap so as to block flow of the liquid medicament through the ejection opening any time the removable cap is coupled with the end cap.
4. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , wherein:
the cartridge further comprises a check valve disposed between the end cap and the reservoir that is configured to permit only one-way flow in an outward direction from the reservoir to the ejection opening to block microbial ingress into the reservoir from the ejection opening.
5. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , wherein:
the piston extends an entire distance between opposing sidewalls of the reservoir;
the piston is solid so as to prevent the liquid medicament from passing through and/or beyond the piston; and
the piston seals a distal end of the cartridge that is spaced apart from a proximal end of the cartridge.
6. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , further comprising:
passing the inspiratory flow through a restrictor array prior to entraining the aerosolized medicament.
7. The method of delivering an aerosolized medication to a user's respiratory system of claim 1 , wherein:
the filter element is configured to inhibit microbial ingress into the cartridge.
8. A method of delivering an aerosolized medication to a user's respiratory system, comprising:
detecting an inhalation by a user using an inhalation monitoring system;
communicating a signal to a piston actuation system, the signal indicating that the inhalation has been detected;
in response to receiving the signal, displacing, using the piston actuation system, a piston that is positioned at a distal end of a reservoir of a cartridge to force a volume of liquid medicament from the reservoir of the cartridge such that the volume of liquid medicament passes through a check valve that is configured to permit only one-way flow in an outward direction from the reservoir to block microbial ingress into the reservoir;
ejecting the volume of liquid medicament onto a rear face of a mesh of an aerosol generator via an ejection opening of an end cap after the volume of liquid medicament has passed through the check valve, wherein the end cap is positioned on a proximal end of the reservoir opposite the distal end;
vibrating the mesh of the aerosol generator to aerosolize the volume of liquid medicament to produce a plume of aerosolized medicament; and
entraining the aerosolized medicament within inspiratory flow through a mouthpiece of an inhaler.
9. The method of delivering an aerosolized medication to a user's respiratory system of claim 8 , further comprising:
filtering the volume of liquid medicament using a filter element positioned within an end cap of the cartridge prior to ejecting the volume of liquid medicament.
10. The method of delivering an aerosolized medication to a user's respiratory system of claim 8 , wherein:
the piston is air driven.
11. The method of delivering an aerosolized medication to a user's respiratory system of claim 8 , further comprising:
sensing when a patient starts breathing; and
automatically activating the aerosol generator based on the sensed breathing.
12. The method of delivering an aerosolized medication to a user's respiratory system of claim 8 , further comprising:
illuminating at least a portion of a chamber in which the liquid medicament is ejected using an ultraviolet light after entraining the aerosolized medicament within inspiratory flow to provide microbial control between doses.
13. The method of delivering an aerosolized medication to a user's respiratory system of claim 8 , further comprising:
passing the inspiratory flow through a restrictor array prior to entraining the aerosolized medicament.
14. The method of delivering an aerosolized medication to a user's respiratory system of claim 13 , wherein:
the restrictor array is configured to produce laminar flow that surrounds the aerosolized medicament.
15. A method of delivering an aerosolized medication to a user's respiratory system, comprising:
sensing an inhalation of a patient at a mouthpiece of an inhaler;
displacing a piston that is positioned at a distal end of a reservoir of a cartridge to force a volume of liquid medicament from the reservoir of the cartridge based on the sensed inhalation;
filtering the volume of liquid medicament using a filter element disposed within a neck of the cartridge;
introducing the filtered volume of liquid medicament into a proximal end of a conduit defined within an end cap that is coupled with the neck of the cartridge;
ejecting the volume of liquid medicament onto a rear face of a mesh of an aerosol generator via an ejection opening formed at a distal end of the conduit based on the sensed inhalation, wherein the end cap is positioned on a proximal end of the reservoir opposite the distal end;
vibrating the mesh of the aerosol generator to aerosolize the volume of liquid medicament to produce a plume of aerosolized medicament based on the sensed inhalation such that the volume of liquid medicament is aerosolized concurrently with the sensed inhalation; and
entraining the aerosolized medicament within inspiratory flow through the mouthpiece of the inhaler.
16. The method of delivering an aerosolized medication to a user's respiratory system of claim 15 , further comprising:
sensing that the inhalation has stopped; and
pausing production of the aerosolized medicament based on sensing that the inhalation has stopped.
17. The method of delivering an aerosolized medication to a user's respiratory system of claim 15 , wherein:
the cartridge further comprises a check valve disposed between the end cap and the reservoir that is configured to permit only one-way flow in an outward direction from the reservoir to the ejection opening to block microbial ingress into the reservoir from the ejection opening; and
the method further comprises filtering the volume of liquid medicament using a filter element positioned within an end cap of the cartridge prior to ejecting the volume of liquid medicament.
18. The method of delivering an aerosolized medication to a user's respiratory system of claim 17 ,
the filter element is positioned downstream of the check valve.
19. The method of delivering an aerosolized medication to a user's respiratory system of claim 15 , further comprising:
priming the cartridge prior to ejecting the volume of the liquid medicament by displacing the piston until a drop of the liquid medicament is dispensed.
20. The method of delivering an aerosolized medication to a user's respiratory system of claim 19 , further comprising:
sensing, using aerosol generator software, that the mesh is wet; and
stopping the priming based on the sensing that the mesh is wet.