IP Library › Patent Application 16397817
Patent Application
App. No. 16/397,817

TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE

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Quick Facts
Patent No.
US None
App. No.
16/397,817
Abstract

Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.

Claims (9)

1 - 31 . (canceled)

32 . A method of treating multiple sclerosis in a human patient comprising using a compound of Formula (I):

wherein:

R 1 is hydrogen;

R 2 is hydrogen;

n is 0;

X is a pair of hydrogen atoms;

R 3 is hydrogen; and

R 4 is hydrogen.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: VIRSIK, PETER A.; WUSTROW, DAVID J.; ANNAMALAI, THAMIL; MANTHATI, SURESH K.
To: XENOPORT, INC.
Reel/Frame 049537/0132 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: XENOPORT, INC.
To: ARBOR PHARMACEUTICALS, LLC
Reel/Frame 049537/0193 →