Granted Patent
B2
US 11,090,304 · App. 16/402,538 · Granted Aug 17, 2021
KRAS G12C inhibitors and methods of using the same
Inventors:
John Gordon Allen (Newbury Park, CA); Jennifer Rebecca Allen (Newbury Park, CA); Ana Elena Minatti (Los Angeles, CA); Qiufen Xue (Thousand Oaks, CA); Ryan Paul Wurz (Newbury Park, CA); Christopher M. Tegley (Daly City, CA); Alexander J. Pickrell (Westlake Village, CA); Thomas T. Nguyen (Newbury Park, CA); Vu Van Ma (Oak Park, CA); Patricia Lopez (Woodland Hills, PA); Longbin Liu (Thousand Oaks, CA); David John Kopecky (Washington, DC); Michael J. Frohn (Thousand Oaks, CA); Ning Chen (Thousand Oaks, CA); Jian Jeffrey Chen (Camarillo, CA); Aaron C. Siegmund (Ventura, CA); Albert Amegadzie (Moorpark, CA); Nuria A. Tamayo (Newbury Park, CA); Shon Booker (Sherman Oaks, CA); Clifford Goodman (Thousand Oaks, CA); Mary Walton (Burlingame, CA); Nobuko Nishimura (West Hills, CA); Youngsook Shin (Thousand Oaks, CA); Jonathan D. Low (Reseda, CA); Victor J. Cee (Thousand Oaks, CA); Anthony B. Reed (Newbury Park, CA); Hui-Ling Wang (Thousand Oaks, CA); Brian Alan Lanman (Woodland Hills, CA)
Assignee:
Amgen Inc.
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Abstract
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Claims (4)
1. A compound having a structure selected from:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 in the form of a pharmaceutically acceptable salt.
3. A pharmaceutical formulation comprising the compound of claim 1 and a pharmaceutically acceptable excipient.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 18, 2019
From: ALLEN, JOHN GORDON; ALLEN, JENNIFER REBECCA; MINATTI, ANA ELENA; XUE, QIUFEN; WURZ, RYAN PAUL; TEGLEY, CHRISTOPHER M.; PICKRELL, ALEXANDER J.; NGUYEN, THOMAS T.; MA, VU VAN; LOPEZ, PATRICIA; LIU, LONGBIN; KOPECKY, DAVID JOHN; FROHN, MICHAEL J.; CHEN, NING; CHEN, JIAN JEFFREY; SIEGMUND, AARON C.; AMEGADZIE, ALBERT; TAMAYO, NURIA A.; BOOKER, SHON; GOODMAN, CLIFFORD; WALTON, MARY; NISHIMURA, NOBUKO; SHIN, YOUNGSOOK; LOW, JONATHAN D.; CEE, VICTOR J.; REED, ANTHONY B.; WANG, HUI-LING; LANMAN, BRIAN ALAN
To: AMGEN INC.
Reel/Frame 050415/0568 →
Continuity (2)
Provisional Application
62667282
· May 4, 2018