Methods for treating lymphoma
Compositions and methods for treating lymphoma, in particular, T-cell lymphoma and follicular lymphoma, in a human patient are provided. The methods entail administering to the patient an effective amount of cerdulatinib.
1. A method of treating a T-cell lymphoma in a human patient in need thereof, comprising administering to the patient an effective amount of cerdulatinib or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the T-cell lymphoma is relapsed or refractory T-cell lymphoma.
3. The method of claim 1 , wherein the T-cell lymphoma has not been previously treated with an agent for treating T-cell lymphoma.
4. The method of claim 1 , wherein the T-cell lymphoma is selected from peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, follicular T-cell lymphoma, anaplastic large cell lymphoma, enteropathy-associated T-cell lymphoma, adult T-cell leukemia/lymphoma, T-cell leukemia, nasal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, and cutaneous (skin) T-cell lymphoma.
5. The method of claim 1 , wherein the T-cell lymphoma is relapsed or refractory peripheral T-cell lymphoma.
6. The method of claim 1 , wherein the T-cell lymphoma is angioimmunoblastic lymphoma.
7. The method of claim 1 , wherein the T-cell lymphoma is anaplastic large cell lymphoma.
8. The method of claim 1 , wherein the T-cell lymphoma is hepatosplenic T-cell lymphoma.
9. The method of claim 1 , wherein the T-cell lymphoma is enteropathy-associated T-cell lymphoma.
10. The method of claim 1 , wherein the T-cell lymphoma is cutaneous T-cell lymphoma.
11. The method of claim 10 , wherein the cutaneous T-cell lymphoma is mycosis fungoides or Sézary syndrome.
12. The method of claim 1 , further comprising administering to the patient an effective amount of rituximab.
13. The method of claim 1 , wherein the effective amount of cerdulatinib is from about 10 mg to about 45 mg daily.
14. The method of claim 1 , wherein the effective amount of cerdulatinib is from about 15 mg to about 30 mg twice daily.
15. The method claim 1 , wherein the effective amount of cerdulatinib is about 15 mg, 20 mg, 25 mg, or 30 mg twice daily.