IP Library Granted Patent US 11,266,645
Granted Patent B2
US 11,266,645 · App. 16/403,227 · Granted Mar 8, 2022

Methods for treating lymphoma

Inventors: Gregory Coffey (San Carlos, CA); Matthew Birrell (Lafayette, CA); Pamela B. Conley (Palo Alto, CA); John T. Curnutte (Tustin, CA); Anjali Pandey (Fremont, CA); Andrew Steele (Haslemere, GB); Glenn Michelson (Fairfax, CA)
Assignee: Alexion Pharmaceuticals, Inc.
A61K31/506A61K39/3955A61P35/02A61K2039/505
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Quick Facts
Patent No.
US 11,266,645
App. No.
16/403,227
Granted
Mar 8, 2022
Kind
B2
Abstract

Compositions and methods for treating lymphoma, in particular, T-cell lymphoma and follicular lymphoma, in a human patient are provided. The methods entail administering to the patient an effective amount of cerdulatinib.

Claims (15)

1. A method of treating a T-cell lymphoma in a human patient in need thereof, comprising administering to the patient an effective amount of cerdulatinib or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the T-cell lymphoma is relapsed or refractory T-cell lymphoma.

3. The method of claim 1 , wherein the T-cell lymphoma has not been previously treated with an agent for treating T-cell lymphoma.

4. The method of claim 1 , wherein the T-cell lymphoma is selected from peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, follicular T-cell lymphoma, anaplastic large cell lymphoma, enteropathy-associated T-cell lymphoma, adult T-cell leukemia/lymphoma, T-cell leukemia, nasal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, and cutaneous (skin) T-cell lymphoma.

5. The method of claim 1 , wherein the T-cell lymphoma is relapsed or refractory peripheral T-cell lymphoma.

6. The method of claim 1 , wherein the T-cell lymphoma is angioimmunoblastic lymphoma.

7. The method of claim 1 , wherein the T-cell lymphoma is anaplastic large cell lymphoma.

8. The method of claim 1 , wherein the T-cell lymphoma is hepatosplenic T-cell lymphoma.

9. The method of claim 1 , wherein the T-cell lymphoma is enteropathy-associated T-cell lymphoma.

10. The method of claim 1 , wherein the T-cell lymphoma is cutaneous T-cell lymphoma.

11. The method of claim 10 , wherein the cutaneous T-cell lymphoma is mycosis fungoides or Sézary syndrome.

12. The method of claim 1 , further comprising administering to the patient an effective amount of rituximab.

13. The method of claim 1 , wherein the effective amount of cerdulatinib is from about 10 mg to about 45 mg daily.

14. The method of claim 1 , wherein the effective amount of cerdulatinib is from about 15 mg to about 30 mg twice daily.

15. The method claim 1 , wherein the effective amount of cerdulatinib is about 15 mg, 20 mg, 25 mg, or 30 mg twice daily.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2021
From: PORTOLA PHARMACEUTICALS, LLC
To: ALEXION PHARMACEUTICALS, INC.
Reel/Frame 054999/0218 →
CHANGE OF NAME Recorded Jan 12, 2021
From: PORTOLA PHARMACEUTICALS, INC.
To: PORTOLA PHARMACEUTICALS, LLC
Reel/Frame 054975/0183 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2019
From: COFFEY, GREGORY; BIRRELL, MATTHEW; CONLEY, PAMELA B.; CURNUTTE, JOHN T.; PANDEY, ANJALI; STEELE, ANDREW; MICHELSON, GLENN
To: PORTOLA PHARMACEUTICALS, INC.
Reel/Frame 050948/0504 →